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Nefazodone Hcl

Nefazodone Hcl Structure
Nefazodone Hcl structure
CAS No.
82752-99-6
Chemical Name:
Nefazodone Hcl
Synonyms
TFA ≥Serazone;NEFAZODONE;Indole ≥Isatin ≥BMY 13754-1;Hecameg ≥>=98% (HPLC);Chromone ≥Piperine &ge
CBNumber:
CB00125069
Molecular Formula:
C25H33Cl2N5O2
Molecular Weight:
506.47
MDL Number:
MFCD00935760
MOL File:
82752-99-6.mol
MSDS File:
SDS
Last updated:2024-11-04 20:04:50
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Nefazodone Hcl Properties

Melting point 186-188°C
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: ~11 mg/mL at 60 °C
form solid
color white
λmax 248nm(MeOH)(lit.)
Merck 14,6438
CAS DataBase Reference 82752-99-6(CAS DataBase Reference)
FDA UNII 27X63J94GR

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  22-24/25
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  XZ5483009
HS Code  2933595960

Nefazodone Hcl price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N5536 Nefazodone hydrochloride ≥98% (HPLC), solid 82752-99-6 10mg $168 2024-03-01 Buy
Sigma-Aldrich 5.08148 Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem 82752-99-6 10mg $155 2024-03-01 Buy
Sigma-Aldrich 1457902 Nefazodone hydrochloride United States Pharmacopeia (USP) Reference Standard 82752-99-6 200mg $1040 2024-03-01 Buy
TCI Chemical N1030 Nefazodone Hydrochloride >98.0%(HPLC)(T) 82752-99-6 200mg $32 2024-03-01 Buy
TCI Chemical N1030 Nefazodone Hydrochloride >98.0%(HPLC)(T) 82752-99-6 1g $89 2024-03-01 Buy
Product number Packaging Price Buy
N5536 10mg $168 Buy
5.08148 10mg $155 Buy
1457902 200mg $1040 Buy
N1030 200mg $32 Buy
N1030 1g $89 Buy

Nefazodone Hcl Chemical Properties,Uses,Production

Description

Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT2 receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HTIA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a1 -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.

Chemical Properties

White Solid

Originator

Bristol-Myers Squibb (U.S.A.)

Uses

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor

Uses

A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.

Definition

ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.

Manufacturing Process

Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

General Description

Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.

Biological Activity

Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

Nefazodone Hcl Preparation Products And Raw materials

Raw materials

Thionyl chloride Triethyl orthopropionate Α-PHENOXYPROPIONIC ACID HYDRAZINE Sodium nitrite
1-(3-Chlorphenyl)piperazine

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Preparation Products

Nefazodone Hcl Suppliers

Global( 211)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21638 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29885 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15356 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem co.,ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from Nefazodone Hcl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nefazodone pictures 2024-10-24 Nefazodone
83366-66-9
 US $43.00-67.00 / mg 10g TargetMol Chemicals Inc.
Nefazodone pictures 2019-07-06 Nefazodone
83366-66-9
 US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co
Nefazodone hydrochloride pictures 2019-07-06 Nefazodone hydrochloride
82752-99-6
US $1.00 / kg 1kg 98% 100KG Career Henan Chemical Co
  • Nefazodone pictures
  • Nefazodone
    83366-66-9
  • US $43.00-67.00 / mg
  • TargetMol Chemicals Inc.
  • Nefazodone pictures
  • Nefazodone
    83366-66-9
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co

82752-99-6(Nefazodone Hcl)Related Search:

Naphazoline hydrochloride Topotecan hydrochloride Furazolidone Naphazoline Triadimefon
Trazodone Nefazodone Related Compound B,Nefazodone Related Compound B NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts),NEFAZODONE,Nefazodone base,Nefazodone (base and/or unspecified salts) 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Nefazodone Related Compound A,Nefazodone Related Compound A
HYDROXY NEFAZODONE HCL,HYDROXY NEFAZODONE HCL Nefazodone hydrochloride NEFAZODONE , TRAZODONE,NEFAZODONE , TRAZODONE HYDROXY NEFAZODONE-D5 HCL,HYDROXY NEFAZODONE-D5 HCL 5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazole-3-one (intermediate of nefazodone hcl)
Nefazodone Hcl

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NEFAZODONE-D5 HCL 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride Nefazodone HCl Nefazodone hydrochloride NEFAZODONE BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride Nefazodone Hydrochloride (200 mg) 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one BMY 13754-1 Serazone Nefazodone hydrochloride API 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride Nefazodone hydrochlo 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)- >=98% (HPLC) 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4 )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge 3-(4-Methoxyphenyl)pyrazole &ge Boc-N-ethyl glycine &ge Boc-D-a-aminobutyric acid &ge Na-Fmoc-Ne-Z-L-lysine &ge (1,2-Dibromoethyl)benzene &ge Na-Acetyl-L-ornithine &ge Na-Acetyl-D-tryptophan &ge 5,6-Dimethoxyindole &ge Z-L-serine amide &ge TFA &ge Gly-OBg· Boc-4-iodo-L-phenylalanine &ge Boc-S-tert-butyl-L-cysteine dicyclohexylammonium salt &ge D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid &ge (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride &ge 4-Acetamido-2-methylbenzoic acid &ge Methyl 2,4-dioxo-4-(2-thienyl)butanoate &ge 3-(4-Fluorophenyl)-1H-pyrazole-5-carbohydrazide &ge (3-Benzothienyl)-L-b-homoalanine hydrochloride &ge 2-(2H-Tetrazol-5-yl)pyridine &ge (S)-Fmoc-3-amino-2-benzyl-propionic acid &ge 7-Methoxy-1H-indole-3-carbaldehyde &ge 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine &ge 5-Amino-2-methylpyridine &ge Ethyl 3-Amino-3-ethoxyacrylate hydrochloride &ge Fmoc-(4-aminomethyl) benzoic acid &ge Fmoc-3,4-dichloro-L-b-homophenylalanine &ge 1,3-Diacetylindole &ge Fmoc-3-nitro-D-phenylalanine &ge 4-Amino-D-phenylalanine hydrochloride &ge Fmoc-(R)-4-aminopimelic acid 1-tert-butyl ester &ge 5-Azacytidine &ge 1-(2-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbohydrazide &ge 5-(4-Bromophenyl)thiophene-2-carboxylic acid &ge