Nefazodone hydrochloride
- CAS No.
- 82752-99-6
- Chemical Name:
- Nefazodone hydrochloride
- Synonyms
- TFA ≥Serazone;NEFAZODONE;Indole ≥Isatin ≥BMY 13754-1;Hecameg ≥>=98% (HPLC);Chromone ≥Piperine &ge
- CBNumber:
- CB8144863
- Molecular Formula:
- C25H33Cl2N5O2
- Molecular Weight:
- 506.47
- MDL Number:
- MFCD00935760
- MOL File:
- 82752-99-6.mol
- MSDS File:
- SDS
Melting point | 186-188°C |
---|---|
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO: ~11 mg/mL at 60 °C |
form | solid |
color | white |
λmax | 248nm(MeOH)(lit.) |
Merck | 14,6438 |
CAS DataBase Reference | 82752-99-6(CAS DataBase Reference) |
FDA UNII | 27X63J94GR |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Safety Statements | 22-24/25 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | XZ5483009 |
HS Code | 2933595960 |
Nefazodone hydrochloride price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N5536 | Nefazodone hydrochloride ≥98% (HPLC), solid | 82752-99-6 | 10mg | $168 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.08148 | Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem | 82752-99-6 | 10mg | $155 | 2024-03-01 | Buy |
Sigma-Aldrich | 1457902 | Nefazodone hydrochloride United States Pharmacopeia (USP) Reference Standard | 82752-99-6 | 200mg | $1040 | 2024-03-01 | Buy |
TCI Chemical | N1030 | Nefazodone Hydrochloride >98.0%(HPLC)(T) | 82752-99-6 | 200mg | $32 | 2024-03-01 | Buy |
TCI Chemical | N1030 | Nefazodone Hydrochloride >98.0%(HPLC)(T) | 82752-99-6 | 1g | $89 | 2024-03-01 | Buy |
Nefazodone hydrochloride Chemical Properties,Uses,Production
Description
Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT2 receptor antagonist and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to enhance 5-HTIA-mediated neurotransmission. Distinct from the first generation agents such as tricyclic antidepressants, nefazodone has very selective serotonergic effects with negligible affinity for cholinergic and histamine receptors, and low affinity for a1 -adrenergic receptors. Therefore, it has a superior toxicity profile that does not produce agitation, insomnia, and lacks cardiac side effects.
Chemical Properties
White Solid
Originator
Bristol-Myers Squibb (U.S.A.)
Uses
An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor
Uses
A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
Definition
ChEBI: Nefazodone hydrochloride is a hydrochloride. It contains a nefazodone.
Manufacturing Process
Manufacturing process for Moxifloxacin hydrochloride includes these steps as follows: 1. synthesis of 1-(3-Chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride, 1-(3-Chlorophenyl)-4-(hydrazinopropyl)piperazine. 2.Phenoxypropionic acid (249.0 g, 1.50 mol) is dissolved in four equivalents of thionyl chloride (438.0 ml, 6.0 mol) and heated to reflux until the HCl evolution has ceased. The solution is then cooled to room temperature and concentrated under reduced pressure to give 281.0 g (100% yield) of phenoxypropionyl chloride as a brown oil which solidifies on cooling 3.Phenoxypropionyl chloride (9.23 g, 0.05 mol) is dissolved in 100 ml acetone and cooled with an ice bath as sodium azide (3.6 g, 0.055 mol) in 10 ml water is added dropwise. After addition is completed, the reaction mixture is warmed to room temperature and stirred for 30 minutes. The solution is decanted and concentrated. The residue is dissolved in 100 ml ether and washed with saturated sodium bicarbonate and brine. The organic phase is separated, dried (MgSO4) and concentrated to give 6.52 g (68.0% yield) of phenoxypropionyl azide as a yellow oil which solidifies on cooling. 4.Synthesis of Ethyl phenoxypropionate, Phenoxypropionyl hydrazide, Phenoxyethyl isocyanate, 2-3-(4-[3-Chlorophenyl]-1-piperazinyl)propyl]-4-(2-phenoxyethyl)- semicarbazide), and 2-[3-4-(3-Chlorophenyl)-1-piperazinyl]-propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one monohydrochloride (Nefazodone monohydrochloride).
brand name
Serzone (Bristol-Myers Squibb).
Therapeutic Function
Antidepressant
General Description
Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
Biological Activity
Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.
Biochem/physiol Actions
Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.
Nefazodone hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3493 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 882 | 58 |
View Lastest Price from Nefazodone hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2020-04-27 | Nefazodone hydrochloride
82752-99-6
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
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2019-07-06 | Nefazodone hydrochloride
82752-99-6
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- Nefazodone hydrochloride
82752-99-6
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Nefazodone hydrochloride
82752-99-6
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
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