Ethinyl Estradiol
- CAS No.
- 57-63-6
- Chemical Name:
- Ethinyl Estradiol
- Synonyms
- ETHINYL ESTRADIOL;ETHYNYLESTRADIOL;17α-Ethynylestradiol;Estradio;17a-ethinylestradiol;17ALPHA-ETHYNYLESTRADIOL;(8R,9S,13S,14S,17R)-17-ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;eed;17-Ethinylestradiol;LYNORAL
- CBNumber:
- CB00126506
- Molecular Formula:
- C20H24O2
- Molecular Weight:
- 296.41
- MDL Number:
- MFCD00003690
- MOL File:
- 57-63-6.mol
- MSDS File:
- SDS
Melting point | 182-183 °C(lit.) |
---|---|
Boiling point | 378°C (rough estimate) |
Density | 1.0944 (rough estimate) |
refractive index | -30 ° (C=0.4, Pyridine) |
Flash point | 9℃ |
storage temp. | room temp |
solubility | ethanol: 50 mg/mL, clear, slightly yellow |
pka | pKa 10.32 (Uncertain) |
form | Solid |
color | White to Light yellow to Light orange |
Merck | 14,3734 |
BRN | 2419975 |
BCS Class | 3/1 |
InChIKey | BFPYWIDHMRZLRN-SLHNCBLASA-N |
CAS DataBase Reference | 57-63-6(CAS DataBase Reference) |
FDA UNII | 423D2T571U |
Proposition 65 List | Ethinylestradiol |
NCI Drug Dictionary | Estinyl |
ATC code | G03CA01,L02AA03 |
NIST Chemistry Reference | Ethinyl estradiol(57-63-6) |
EPA Substance Registry System | Ethinyl estradiol (57-63-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08,GHS09 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H350-H410 | |||||||||
Precautionary statements | P202-P264-P270-P273-P301+P312-P308+P313 | |||||||||
Hazard Codes | T,F | |||||||||
Risk Statements | 45-22-39/23/24/25-23/24/25-11 | |||||||||
Safety Statements | 53-36/37/39-45-36/37-16 | |||||||||
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
WGK Germany | 3 | |||||||||
RTECS | RC8925000 | |||||||||
F | 8 | |||||||||
HS Code | 29372390 | |||||||||
Toxicity | LD50 oral in rat: 960mg/kg | |||||||||
NFPA 704 |
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Ethinyl Estradiol price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | E-076 | 17α-Ethynylestradiol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 57-63-6 | 1mL | $131 | 2024-03-01 | Buy |
Sigma-Aldrich | BP421 | Ethinylestradiol British Pharmacopoeia (BP) Assay Standard | 57-63-6 | 100MG | $257 | 2024-03-01 | Buy |
Sigma-Aldrich | 1260001 | Ethinyl estradiol United States Pharmacopeia (USP) Reference Standard | 57-63-6 | 150mg | $348.8 | 2024-03-01 | Buy |
TCI Chemical | E0037 | Ethynylestradiol >98.0%(HPLC)(T) | 57-63-6 | 1g | $71 | 2024-03-01 | Buy |
TCI Chemical | E0037 | Ethynylestradiol | 57-63-6 | 5G | $213 | 2024-03-01 | Buy |
Ethinyl Estradiol Chemical Properties,Uses,Production
Description
Ethinyl Estradiol is a fine white to creamy white powder. It is a synthetic steroid. Used in combination with progestogen as an oral contraceptive. 17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid.
Uses
Drospirenone; Ethinyl Estradiol: prevents ovulation and pregnancy. It may also be used to treat acne and premenstrual dysphoric disorder (PMDD). It belongs to a group of medications called oral contraceptives. It is a combination of the hormones estrogen and progestin.
Toxicology
Ethinyl estradiol (EO, a semisynthetic 17 β-oestradiol) is the highly potent estrogen. The median lethal dose (LD50) of EO has been determined to be more than 1000 μg/kg body weight, orally in female albino rats. EO caused the cytotoxicity, leading to cancer in the uterus and ovary of female albino rat. Further, EO @ 500 μg/kg, orally, weekly for 8 and 12 weeks has been reported to cause liver damage in female albino rat.
Synthesis
Ethinyl estradiol, 17α-ethinyl-1,3,5(10)-estratrien-3-17β-diol (28.1.26), is made either by condensing estrone with acetylene in the presence of potassium hydroxide (Favorskii reaction), or by reacting sodium acetylenide in liquid ammonia with estrone.
Ethinyl Estradiol Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales03@airuikechemical.com | China | 961 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3149 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 284 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20370 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21677 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9338 | 55 |
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- Mar 20,2024
View Lastest Price from Ethinyl Estradiol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-08-21 | Sodium tetraborate pentahydrate
12179-04-3
|
1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |
- Sodium tetraborate pentahydrate
12179-04-3
- 99%
- Anhui Ruihan Technology Co., Ltd
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