ChemicalBook >> CAS DataBase List >>Ethinyl Estradiol
Ethinyl Estradiol
- CAS No.
- 57-63-6
- Chemical Name:
- Ethinyl Estradiol
- Synonyms
- ETHINYL ESTRADIOL;ETHYNYLESTRADIOL;17α-Ethynylestradiol;Estradio;17a-ethinylestradiol;17ALPHA-ETHYNYLESTRADIOL;(8R,9S,13S,14S,17R)-17-ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;eed;17-Ethinylestradiol;LYNORAL
- CBNumber:
- CB00126506
- Molecular Formula:
- C20H24O2
- Molecular Weight:
- 296.41
- MDL Number:
- MFCD00003690
- MOL File:
- 57-63-6.mol
- MSDS File:
- SDS
Last updated:2024-07-10 15:15:42
| Melting point | 182-183 °C(lit.) |
|---|---|
| Boiling point | 378°C (rough estimate) |
| Density | 1.0944 (rough estimate) |
| refractive index | -30 ° (C=0.4, Pyridine) |
| Flash point | 9℃ |
| storage temp. | room temp |
| solubility | ethanol: 50 mg/mL, clear, slightly yellow |
| pka | pKa 10.32 (Uncertain) |
| form | Solid |
| color | White to Light yellow to Light orange |
| Merck | 14,3734 |
| BRN | 2419975 |
| BCS Class | 3/1 |
| InChIKey | BFPYWIDHMRZLRN-SLHNCBLASA-N |
| CAS DataBase Reference | 57-63-6(CAS DataBase Reference) |
| FDA UNII | 423D2T571U |
| Proposition 65 List | Ethinylestradiol |
| NCI Drug Dictionary | Estinyl |
| ATC code | G03CA01,L02AA03 |
| NIST Chemistry Reference | Ethinyl estradiol(57-63-6) |
| EPA Substance Registry System | Ethinyl estradiol (57-63-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H350-H410 | |||||||||
| Precautionary statements | P202-P264-P270-P273-P301+P312-P308+P313 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 45-22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 53-36/37/39-45-36/37-16 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC8925000 | |||||||||
| F | 8 | |||||||||
| HS Code | 29372390 | |||||||||
| Toxicity | LD50 oral in rat: 960mg/kg | |||||||||
| NFPA 704 |
|
Ethinyl Estradiol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E-076 | 17α-Ethynylestradiol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 57-63-6 | 1mL | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP421 | Ethinylestradiol British Pharmacopoeia (BP) Assay Standard | 57-63-6 | 100MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1260001 | Ethinyl estradiol United States Pharmacopeia (USP) Reference Standard | 57-63-6 | 150mg | $348.8 | 2024-03-01 | Buy |
| TCI Chemical | E0037 | Ethynylestradiol >98.0%(HPLC)(T) | 57-63-6 | 1g | $71 | 2024-03-01 | Buy |
| TCI Chemical | E0037 | Ethynylestradiol | 57-63-6 | 5G | $213 | 2024-03-01 | Buy |
Ethinyl Estradiol Chemical Properties,Uses,Production
Description
Ethinyl Estradiol is a fine white to creamy white powder. It is a synthetic steroid. Used in combination with progestogen as an oral contraceptive. 17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid.
Uses
Drospirenone; Ethinyl Estradiol: prevents ovulation and pregnancy. It may also be used to treat acne and premenstrual dysphoric disorder (PMDD). It belongs to a group of medications called oral contraceptives. It is a combination of the hormones estrogen and progestin.
Toxicology
Ethinyl estradiol (EO, a semisynthetic 17 β-oestradiol) is the highly potent estrogen. The median lethal dose (LD50) of EO has been determined to be more than 1000 μg/kg body weight, orally in female albino rats. EO caused the cytotoxicity, leading to cancer in the uterus and ovary of female albino rat. Further, EO @ 500 μg/kg, orally, weekly for 8 and 12 weeks has been reported to cause liver damage in female albino rat.
Synthesis
Ethinyl estradiol, 17α-ethinyl-1,3,5(10)-estratrien-3-17β-diol (28.1.26), is made either by condensing estrone with acetylene in the presence of potassium hydroxide (Favorskii reaction), or by reacting sodium acetylenide in liquid ammonia with estrone.
Ethinyl Estradiol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 541)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales03@airuikechemical.com | China | 983 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3146 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 292 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10978 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20314 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21671 | 55 |
Related articles
- Levonorgestrel-Ethinyl Estradiol Oral: uses and side effects
- This combination hormone medication Levonorgestrel-Ethinyl Estradiol is used to prevent pregnancy.
- Mar 20，2024
View Lastest Price from Ethinyl Estradiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-21 | Sodium tetraborate pentahydrate
12179-04-3
|
1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |
-
- Sodium tetraborate pentahydrate
12179-04-3
- 99%
- Anhui Ruihan Technology Co., Ltd
57-63-6(Ethinyl Estradiol)Related Search:
3-thietan-1-ol
Quinestrol
Estradiol
17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether
Nilestriol
ETHINYLESTRADIOL IMP. C (EP): 3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE (ESTRONE)
ETHINYLESTRADIOL IMP. D (EP) AS HEMIHYDRATE: ESTRADIOL HEMIHYDRATE
ETHINYL ESTRADIOL RELATED COMPOUND A (20 MG) (6-KETO-ETHINYL ESTRADIOL)
2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL
ESTRADIOL HEMIHYDRATE
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19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17ALPHA-DIOL
19-NOR-1,3,5[10],17ALPHA-PREGNATRIEN-20-YNE-3,17-DIOL
1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL
ACETENYL ESTRADIOL
17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL
17-ALPHA-ETHYNLESTRADIOL
17ALPHA-ETHYNYL-1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol
17 A-ETHYNYLESTRADIOL
17alpha-ethinylestra-1,3,5(10)-triene-3,17beta-diol
(17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17,diol
17-alpha-ethinyl-17-beta-estradiol
17alpha-Ethinyl-17beta-estradiol
17alpha-Ethinyl-3,17-dihydroxy-delta(sup1,3,5)-estratriene
17alpha-ethinyl-3,17-dihydroxy-delta(sup1,3,5)oestratriene
17alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta -diol
17-alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta-diol
17-alpha-ethinylestra-1,3,5(10)-triene-3,17-beta-diol
NOVESTROL
NEO-ESTRONE
17A-ETHYNYLESTRADIOL VETRANAL, 250 MG
(1S,10R,11S,14S,15S)-14-ethynyl-15-Methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
Ethinylestradiol Solution, 100ppm
17α-Ethynylestradiol solution
Ethinylestradiol Imp.(EP)
Ethinylestradio
(8R,9S,13S,14S)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
17alpha-ethynyl-3,17-dihydroxy-delta-(sup1,3,5)-estratriene
17alpha-Ethynyl-3-hydroxy-1,3,5(10)-estratrien-17beta-ol
estroals
primogyn c(or m)
roldiol
Quinestriol
19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol
19-nor-17-alpha-pregna-1,3,5(10)-triene-20-yne-3,17-diol
19Nor-17-pregna-1,3,5-(10)-trien-20yne-3,17-diol
diprol
Dyloform
ee(sub2)
Ertonyl
Esteed
Estigyn
Estoral
Estoral (orion)
estoral(orion)
Estorals
Estra-1,3,5(10)-triene-3,17beta-diol, 17alpha-ethynyl-
Estra-1,3,5(10)-triene-3,17beta-diol, 17-ethynyl-
Estradiol, 17-ethynyl-
estradiol,17-ethynyl-
Ethidol
Ethinoral
Ethinylestriol
ethinyloestriol
ethynyloestradiol
Eticyclin
Eticyclol
Eticylol