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Ethinyl Estradiol

CAS No.
57-63-6
Chemical Name:
Ethinyl Estradiol
Synonyms
ETHINYL ESTRADIOL;ETHYNYLESTRADIOL;17α-Ethynylestradiol;Estradio;17a-ethinylestradiol;17ALPHA-ETHYNYLESTRADIOL;(8R,9S,13S,14S,17R)-17-ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;eed;17-Ethinylestradiol;LYNORAL
CBNumber:
CB00126506
Molecular Formula:
C20H24O2
Molecular Weight:
296.41
MDL Number:
MFCD00003690
MOL File:
57-63-6.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:00

Ethinyl Estradiol Properties

Melting point 182-183 °C(lit.)
Boiling point 378°C (rough estimate)
Density 1.0944 (rough estimate)
refractive index -30 ° (C=0.4, Pyridine)
Flash point 9℃
storage temp. room temp
solubility ethanol: 50 mg/mL, clear, slightly yellow
pka pKa 10.32 (Uncertain)
form Solid
color White to Light yellow to Light orange
Merck 14,3734
BRN 2419975
BCS Class 3/1
InChIKey BFPYWIDHMRZLRN-SLHNCBLASA-N
CAS DataBase Reference 57-63-6(CAS DataBase Reference)
FDA UNII 423D2T571U
Proposition 65 List Ethinylestradiol
NCI Drug Dictionary Estinyl
ATC code G03CA01,L02AA03
NIST Chemistry Reference Ethinyl estradiol(57-63-6)
EPA Substance Registry System Ethinyl estradiol (57-63-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H350-H410
Precautionary statements  P202-P264-P270-P273-P301+P312-P308+P313
Hazard Codes  T,F
Risk Statements  45-22-39/23/24/25-23/24/25-11
Safety Statements  53-36/37/39-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  RC8925000
8
HS Code  29372390
Toxicity LD50 oral in rat: 960mg/kg
NFPA 704
0
1 0

Ethinyl Estradiol price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E-076 17α-Ethynylestradiol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 57-63-6 1mL $131 2024-03-01 Buy
Sigma-Aldrich BP421 Ethinylestradiol British Pharmacopoeia (BP) Assay Standard 57-63-6 100MG $257 2024-03-01 Buy
Sigma-Aldrich 1260001 Ethinyl estradiol United States Pharmacopeia (USP) Reference Standard 57-63-6 150mg $348.8 2024-03-01 Buy
TCI Chemical E0037 Ethynylestradiol >98.0%(HPLC)(T) 57-63-6 1g $71 2024-03-01 Buy
TCI Chemical E0037 Ethynylestradiol 57-63-6 5G $213 2024-03-01 Buy
Product number Packaging Price Buy
E-076 1mL $131 Buy
BP421 100MG $257 Buy
1260001 150mg $348.8 Buy
E0037 1g $71 Buy
E0037 5G $213 Buy

Ethinyl Estradiol Chemical Properties,Uses,Production

Description

Ethinyl Estradiol is a fine white to creamy white powder. It is a synthetic steroid. Used in combination with progestogen as an oral contraceptive. 17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid.

Uses

Drospirenone; Ethinyl Estradiol: prevents ovulation and pregnancy. It may also be used to treat acne and premenstrual dysphoric disorder (PMDD). It belongs to a group of medications called oral contraceptives. It is a combination of the hormones estrogen and progestin.

Toxicology

Ethinyl estradiol (EO, a semisynthetic 17 β-oestradiol) is the highly potent estrogen. The median lethal dose (LD50) of EO has been determined to be more than 1000 μg/kg body weight, orally in female albino rats. EO caused the cytotoxicity, leading to cancer in the uterus and ovary of female albino rat. Further, EO @ 500 μg/kg, orally, weekly for 8 and 12 weeks has been reported to cause liver damage in female albino rat.

Synthesis

Ethinyl estradiol, 17α-ethinyl-1,3,5(10)-estratrien-3-17β-diol (28.1.26), is made either by condensing estrone with acetylene in the presence of potassium hydroxide (Favorskii reaction), or by reacting sodium acetylenide in liquid ammonia with estrone.

Global( 540)Suppliers
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Wuhan Han Sheng New Material Technology Co.,Ltd
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1kg 99% 100tons Anhui Ruihan Technology Co., Ltd
19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17ALPHA-DIOL 19-NOR-1,3,5[10],17ALPHA-PREGNATRIEN-20-YNE-3,17-DIOL 1,3,5(10)-ESTRATRIEN-17-ALPHA-ETHYNYL-3,17-BETA-DIOL ACETENYL ESTRADIOL 17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL 17-ALPHA-ETHYNLESTRADIOL 17ALPHA-ETHYNYL-1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 17 A-ETHYNYLESTRADIOL 17alpha-ethinylestra-1,3,5(10)-triene-3,17beta-diol (17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17,diol 17-alpha-ethinyl-17-beta-estradiol 17alpha-Ethinyl-17beta-estradiol 17alpha-Ethinyl-3,17-dihydroxy-delta(sup1,3,5)-estratriene 17alpha-ethinyl-3,17-dihydroxy-delta(sup1,3,5)oestratriene 17alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta -diol 17-alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta-diol 17-alpha-ethinylestra-1,3,5(10)-triene-3,17-beta-diol NOVESTROL NEO-ESTRONE 17A-ETHYNYLESTRADIOL VETRANAL, 250 MG (1S,10R,11S,14S,15S)-14-ethynyl-15-Methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol Ethinylestradiol Solution, 100ppm 17α-Ethynylestradiol solution Ethinylestradiol Imp.(EP) Ethinylestradio (8R,9S,13S,14S)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 17alpha-ethynyl-3,17-dihydroxy-delta-(sup1,3,5)-estratriene 17alpha-Ethynyl-3-hydroxy-1,3,5(10)-estratrien-17beta-ol estroals primogyn c(or m) roldiol Quinestriol 19-Nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol 19-nor-17-alpha-pregna-1,3,5(10)-triene-20-yne-3,17-diol 19Nor-17-pregna-1,3,5-(10)-trien-20yne-3,17-diol diprol Dyloform ee(sub2) Ertonyl Esteed Estigyn Estoral Estoral (orion) estoral(orion) Estorals Estra-1,3,5(10)-triene-3,17beta-diol, 17alpha-ethynyl- Estra-1,3,5(10)-triene-3,17beta-diol, 17-ethynyl- Estradiol, 17-ethynyl- estradiol,17-ethynyl- Ethidol Ethinoral Ethinylestriol ethinyloestriol ethynyloestradiol Eticyclin Eticyclol Eticylol