ChemicalBook >> CAS DataBase List >>ST1481
ST1481
- CAS No.
- 292618-32-7
- Chemical Name:
- ST1481
- Synonyms
- ST1481;Lbq707;STI481;CPT 184;GIMATECAN;Unii-7kks9R192f;ST1481: GIMATECAN;LBQ707; ST1481; CPT 184;ST1481 ST-1481 Gimatecan;7-T-Butoxyiminomethylcamptothecin
- CBNumber:
- CB01011641
- Molecular Formula:
- C25H25N3O5
- Molecular Weight:
- 447.488
- MDL Number:
- MFCD06795143
- MOL File:
- 292618-32-7.mol
Last updated:2024-11-14 20:10:21
| Boiling point | 780.6±70.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 11.20±0.20(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| NCI Dictionary of Cancer Terms | gimatecan; ST1481 |
| FDA UNII | 7KKS9R192F |
| NCI Drug Dictionary | gimatecan |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H335-H319-H351-H315 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
ST1481 Chemical Properties,Uses,Production
Biological Activity
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.
in vivo
Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.
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| Animal Model: | Athymic Swiss nude mice bearing HT1376 model | ||||
| Dosage: | 2 mg/kg | ||||
| Administration: | Treatment per os, every fourth day for four times | ||||
| Result: | Caused a marked tumor growth inhibition during treatment. |
| Topoisomerase I
|
ST1481 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 42)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32080 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 2998 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
292618-32-7(ST1481)Related Search:
GIMATECAN
ST1481
ST1481: GIMATECAN
(4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)-
7-T-Butoxyiminomethylcamptothecin
Lbq707
Unii-7kks9R192f
CPT 184
LBQ707; ST1481; CPT 184
7-[(E)-tert-butyloxyiminomethyl]-camptothecin
STI481
ST1481 ST-1481 Gimatecan
(S,E)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl) oxime
292618-32-7