Indole-4-carboxaldehyde
- CAS No.
- 1074-86-8
- Chemical Name:
- Indole-4-carboxaldehyde
- Synonyms
- 4-INDOLECARBALDEHYDE;1H-INDOLE-4-CARBALDEHYDE;4-FLUOROINDOLE;1H-INDOLE-4-CARBOXALDEHYDE;NSC 337264;e-4-carboxaL;4-FORMYLINDOLE;INDOLE-4-ALDEHYDE;4-Formyl-1H-indole;RARECHEM AH BS 0110
- CBNumber:
- CB0217303
- Molecular Formula:
- C9H7NO
- Molecular Weight:
- 145.16
- MDL Number:
- MFCD01632221
- MOL File:
- 1074-86-8.mol
- MSDS File:
- SDS
Melting point | 139-143 °C(lit.) |
---|---|
Boiling point | 339.1±15.0 °C(Predicted) |
Density | 1.278±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
form | powder to crystal |
pka | 15.84±0.30(Predicted) |
color | Light yellow to Brown |
Water Solubility | Soluble in ethanol and acetone. Insoluble in water. |
Sensitive | Air Sensitive |
InChI | InChI=1S/C9H7NO/c11-6-7-2-1-3-9-8(7)4-5-10-9/h1-6,10H |
InChIKey | JFDDFGLNZWNJTK-UHFFFAOYSA-N |
SMILES | N1C2=C(C(C=O)=CC=C2)C=C1 |
CAS DataBase Reference | 1074-86-8(CAS DataBase Reference) |
NIST Chemistry Reference | 1H-indole-4-carboxaldehyde(1074-86-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H317-H319 | |||||||||
Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36-43 | |||||||||
Safety Statements | 26-36/37 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant/Keep Cold | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
|
Indole-4-carboxaldehyde price More Price(42)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 1g | $129 | 2023-06-20 | Buy |
Sigma-Aldrich | 632422 | Indole-4-carboxaldehyde 97% | 1074-86-8 | 5g | $628 | 2023-06-20 | Buy |
TCI Chemical | I0712 | Indole-4-carboxaldehyde >98.0%(GC) | 1074-86-8 | 1g | $160 | 2024-03-01 | Buy |
TCI Chemical | I0712 | Indole-4-carboxaldehyde >98.0%(GC) | 1074-86-8 | 5g | $400 | 2024-03-01 | Buy |
Alfa Aesar | H28019 | Indole-4-carboxaldehyde, 97% | 1074-86-8 | 5g | $713 | 2021-12-16 | Buy |
Indole-4-carboxaldehyde Chemical Properties,Uses,Production
Chemical Properties
White to dark brown solid
Uses
4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.
Uses
Indole-4-carboxaldehyde is usually used as reactant in Biginelli reaction,preparation of antitumor agents,intramolecular Friedel-Crafts acylation,preparation of inhibitors of cell division in E. Coli,synthesis of Hantzsch pyridine-containing Schiff bases.
Definition
ChEBI: Indole-4-carbaldehyde is a heteroarenecarbaldehyde that is indole in which the hydrogen at position 4 has been replaced by a formyl group. It has a role as an algal metabolite. It is a member of indoles and a heteroarenecarbaldehyde.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 1752, 1981 DOI: 10.1021/jo00321a053
Tetrahedron, 39, p. 3695, 1983 DOI: 10.1016/S0040-4020(01)88608-7
General Description
Indole-4-carboxaldehyde participates in the synthesis of arcyriacyanin A. Synthesis of 4-indole-4-carboxaldehyde has been reported. Intramolecular Friedel-Crafts (FC) acylation of indole-4-carboxaldehyde has been reported.
Synthesis
Tetrapropylammonium perruthenate (0.3 g, 0.85 mmol) was added in portions to a mixture of alcohol product from 1H-Indole-4-Methanol (2.5 g, 17 mmol), N-methylmorpholine N-oxide (3.0 g, 25 mmol) and 4 A molecular sieves (3.0 g) in anhydrous methylene chloride (30 mL) at room temperature. The mixture was stirred at room temperature under nitrogen for 1 h and then filtered. The filtrate was concentrated in vacuo, and the residue was purified by chromatography (SiO2, CH2Cl2) to provide Indole-4-carboxaldehyde as a white powder (2.0 g, 80percent): 1H NMR (300 MHz, CDCl3) δ10.2 (s, 1H), 8.52 (br s, 1H), 7.64-7.69 (m, 2H), 7.31-7.44 (m, 3H), CI MS m/z=146 [C9H7NO+H]+.
Indole-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Fengmu Trading Co., Ltd. | +8613393234347 | Lyla@fengmuchem.com | China | 2982 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19372 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
View Lastest Price from Indole-4-carboxaldehyde manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-08-12 | Indole-4-carboxaldehyde
1074-86-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-02 | Indole-4-carboxaldehyde
1074-86-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-12-31 | Indole-4-carboxaldehyde
1074-86-8
|
US $1.00 / KG | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
- Indole-4-carboxaldehyde
1074-86-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Indole-4-carboxaldehyde
1074-86-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Indole-4-carboxaldehyde
1074-86-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
1074-86-8(Indole-4-carboxaldehyde)Related Search:
1of4