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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

CAS No.
365998-36-3
Chemical Name:
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
Synonyms
CarbaMic acid, N-[(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]-, 1,1-diMethylethyl ester;Edoxaban INTERMEDIATES Ⅰ;tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate;(1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine;D-1315;(5H-Pyrrolo[3;Edoxaban Impurity 47;Paracetamol Impurity 27;InterMediate of Edoxaban;Edoxaban INTERMEDIATES Ⅲ
CBNumber:
CB02652836
Molecular Formula:
C14H27N3O3
Molecular Weight:
285.38
MDL Number:
MFCD22190570
MOL File:
365998-36-3.mol
MSDS File:
SDS
Last updated:2023-12-21 13:37:30

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Properties

Boiling point 434.4±45.0 °C(Predicted)
Density 1.09±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form Solid
pka 11.90±0.60(Predicted)
CAS DataBase Reference 365998-36-3

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B809495 tert-Butyl[(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate 365998-36-3 1g $250 2021-12-16 Buy
American Custom Chemicals Corporation CCH0065742 TERT-BUTYL N-[(1R,2S,5S)-2-AMINO-5-(DIMETHYLCARBAMOYL)CYCLOHEXYL]CARBAMATE 95.00% 365998-36-3 5MG $458.62 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 365998-36-3 1g $490 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 365998-36-3 5G $790 2021-12-16 Buy
SynQuest Laboratories 4256-1-70 tert-Butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate 97.0% 365998-36-3 250mg $190 2021-12-16 Buy
Product number Packaging Price Buy
B809495 1g $250 Buy
CCH0065742 5MG $458.62 Buy
4256-1-70 1g $490 Buy
4256-1-70 5G $790 Buy
4256-1-70 250mg $190 Buy

tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Chemical Properties,Uses,Production

Description

Tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is a pharmaceutical intermediate compound used in the preparation of Edoxaban. Edoxaban is an oral anticoagulant drug used for the treatment of strokes due to blood clots, thrombosis, heart disease and cirrhosis of the liver.

Uses

Tert-butyl(1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is an organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. It is a reagent used in the synthesis of cis-1,2-diaminocyclohexane derivative. It is also mainly used as raw material to synthesize reversible factor Xa inhibitor drug edoxaban[1]. The drug has been approved by the U.S. Food and Drug Administration as a direct oral anticoagulant and is the fourth direct oral anticoagulant approved for clinical use[2-3].

Referance:[1] Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan, Jan Stasko, Edoxaban affects TRAP-dependent platelet aggregation, Journal of Thrombosis and Thrombolysis, 2020, 49, 578-583.
[2] Juraj Sokol, Frantisek Nehaj, Jela Ivankova, Michal Mokan, Lenka Lisa, Jana Zolkova, Lubica Vadelova, Marian Mokan, Jan Stasko, Impact of Edoxaban on Thrombin-Dependent Platelet Aggregation,Clinical and Applied Thrombosis/Hemostasis, 2020.
[3] Mara Poulakos, Jacqueline N Walker, Umima Baig, Tosin David, Edoxaban: A direct oral anticoagulant, American Journal of Health-System Pharmacy, 2017,74, 117–129.

480450-69-9
365998-36-3
Synthesis of tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate from Edoxaban Impurity 16
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View Lastest Price from tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate pictures 2023-09-08 tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
365998-36-3
US $30.00 / kg 1kg 99% 20 tons Anhui Ruihan Technology Co., Ltd
Tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethyl carbamoyl) cyclohexyl) carbamate pictures 2023-09-08 Tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethyl carbamoyl) cyclohexyl) carbamate
365998-36-3
US $0.00 / KG Ton 1KG Ton 99%+ 2 tons/month Zhuhai Hairuide Bioscience and Technology Co., Ltd
tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate pictures 2022-09-08 tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate
365998-36-3
US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
Edoxaban INTERMEDIATES Ⅱ Edoxaban INTERMEDIATES Ⅲ InterMediate of Edoxaban Tert-Butyl [(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]carbaMate(for Edoxaban) Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester, ethanedioate (1:1) N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl] -, 1,1-dimethylethyl ester D-1315 (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl este (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]c N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamic acid 1,1-dimethylethyl ester (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl esterChemicalBook (5H-Pyrrolo[3 4-d]thiazole-5-carboxylic acid 5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4 Carbamic acid,[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-,1,1-dimethylethyl ester [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate ert-butylN-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl este Edoxaban Impurity 47 Carbamic acid,[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl... Edoxaban INTERMEDIATES Ⅰ tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate (1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine CarbaMic acid, N-[(1R,2S,5S)-2-aMino-5-[(diMethylaMino)carbonyl]cyclohexyl]-, 1,1-diMethylethyl ester (1R,2S,5S)-2-amino-5-[(dimethylamino) carbonyl]cyclohexyl]-,1,1-dimethylethy l ester tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate ethanedioate tert-butyl (1R,2S,5S)-5-(dimethylcarbamoyl)-2-aminocyclohexylcarbamate Edoxaban Impurity 29 Monomer Paracetamol Impurity 27 tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Edoxaban Impurity 30 (1R,2S,5S) 365998-36-3 1243308-37-7