PTP Inhibitor III
- CAS No.
- 29936-81-0
- Chemical Name:
- PTP Inhibitor III
- Synonyms
- PTP Inhibitor III;4-(bromoacetyl)phenoxyacetic acid;2-[4-(2-bromoacetyl)phenoxy]-aceticacid;Acetic acid, 2-[4-(2-bromoacetyl)phenoxy]-;PTP Inhibitor III - CAS 29936-81-0 - Calbiochem;PTP Inhibitor III (4-(Bromoacetyl)phenoxyacetic Acid)
- CBNumber:
- CB03136762
- Molecular Formula:
- C10H9BrO4
- Molecular Weight:
- 273.08
- MDL Number:
- MOL File:
- 29936-81-0.mol
PTP Inhibitor III price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19059 | PTP Inhibitor III ≥95% | 29936-81-0 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 19059 | PTP Inhibitor III ≥95% | 29936-81-0 | 5mg | $163 | 2024-03-01 | Buy |
| Cayman Chemical | 19059 | PTP Inhibitor III ≥95% | 29936-81-0 | 10mg | $239 | 2024-03-01 | Buy |
| AK Scientific | 0563CA | 4-(Bromoacetyl)phenoxyaceticacid | 29936-81-0 | 10mg | $364 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | COR0003719 | ALPHA-BROMO-4-(CARBOXYMETHOXY)ACETOPHENONE 95.00% | 29936-81-0 | 1G | $1030.84 | 2021-12-16 | Buy |
PTP Inhibitor III Chemical Properties,Uses,Production
Description
PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2? Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3
Uses
PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs). It binds the catalytic domain of SHP-1 (Ki = 184 μM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.[Cayman Chemical]
References
Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518 Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1 Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597
PTP Inhibitor III Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3453 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5594 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |