3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
- CAS No.
- 952143-02-1
- Chemical Name:
- 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
- Synonyms
- 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine;3H-Diazirine, 3-(4-bromophenyl)-3-(trifluoromethyl)-;3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
- CBNumber:
- CB05430590
- Molecular Formula:
- C8H4BrF3N2
- Molecular Weight:
- 265.03
- MDL Number:
- MOL File:
- 952143-02-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H314 |
| Precautionary statements | P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405 |
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 906298 | 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine | 952143-02-1 | 50mg | $239 | 2024-03-01 | Buy |
| AK Scientific | 6535CX | 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine | 952143-02-1 | 2.5g | $2705 | 2021-12-16 | Buy |
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Chemical Properties,Uses,Production
Uses
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.
reaction suitability
reagent type: cross-linking reagent
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Preparation Products And Raw materials
Raw materials
Preparation Products
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 55017 | 58 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310; | sales@chemshuttle.com | China | 2999 | 62 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Taizhou GreenChem Pharmaceutical Co., Ltd. | 0514-86654616 15366892466 | greenchem@tzglmk.com | China | 498 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. | 15990591583 | China | 5576 | 58 | |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9964 | 58 |
| Milestone Chemical Wuxi Co.,Ltd | 18068271528 | 1917265470@qq.com | China | 71 | 58 |
| Tianjin Kaimu Chemical Technology Co., LTD | 18522952724 18522952724 | kaimuchem@163.com | China | 484 | 58 |