BIS(METHYLTHIO)GLIOTOXIN
- CAS No.
- 74149-38-5
- Chemical Name:
- BIS(METHYLTHIO)GLIOTOXIN
- Synonyms
- FR-49175;BIS(METHYLTHIO)GLIOTOXIN;Bis(methylthio)gliotoxin (FR-49175);bis-dethio-bis(methylthio)gliotoxin;gliotoxin, bis-dethio-bis(methylthio)-;Bis(methylthio)gliotoxin, platelet-activating factor (PAF) receptor antagonist;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
- CBNumber:
- CB1288191
- Molecular Formula:
- C15H20N2O4S2
- Molecular Weight:
- 356.46
- MDL Number:
- MFCD00133146
- MOL File:
- 74149-38-5.mol
- MSDS File:
- SDS
| Boiling point | 669.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | White solid. |
| pka | 12.69±0.60(Predicted) |
| color | Off-White to Yellow |
| biological source | natural |
| Water Solubility | water: soluble |
| UNSPSC Code | 12352205 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264b-P270-P271-P280-P302+P352-P304+P340-P312-P330-P363-P403-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | 1544 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
BIS(METHYLTHIO)GLIOTOXIN price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67499 | Bis(methylthio)gliotoxin, 99% | 74149-38-5 | 1mg | $290 | 2023-06-20 | Buy |
| Cayman Chemical | 26271 | Bis(methylthio)gliotoxin ≥95% | 74149-38-5 | 500μg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 26271 | Bis(methylthio)gliotoxin ≥95% | 74149-38-5 | 1mg | $161 | 2024-03-01 | Buy |
| TRC | B485948 | Bis(methylthio)gliotoxin(FR-49175) | 74149-38-5 | 1mg | $215 | 2021-12-16 | Buy |
| TRC | B485948 | Bis(methylthio)gliotoxin(FR-49175) | 74149-38-5 | 2.5mg | $525 | 2021-12-16 | Buy |
BIS(METHYLTHIO)GLIOTOXIN Chemical Properties,Uses,Production
Description
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
Uses
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.
Enzyme inhibitor
This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.
BIS(METHYLTHIO)GLIOTOXIN Preparation Products And Raw materials
BIS(METHYLTHIO)GLIOTOXIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5653 | 65 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2993 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27313 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 | 3004987436@qq.com | China | 9693 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10524 | 58 |
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