ChemicalBook >> CAS DataBase List >>SR 0987
SR 0987
- CAS No.
- 303126-97-8
- Chemical Name:
- SR 0987
- Synonyms
- SR 0987;SR0987 >=98% (HPLC);SR 0987;SR-0987;SR0987;303126-97-8;SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
- CBNumber:
- CB13152747
- Molecular Formula:
- C16H10ClF6NO2
- Molecular Weight:
- 397.7
- MDL Number:
- MFCD02693203
- MOL File:
- 303126-97-8.mol
Last updated:2024-11-19 20:33:22
| Boiling point | 378.8±42.0 °C(Predicted) |
|---|---|
| Density | 1.525±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml) |
| pka | 9.22±0.15(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
SR 0987 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19503 | SR 0987 ≥98% | 303126-97-8 | 1mg | $27 | 2024-03-01 | Buy |
| Cayman Chemical | 19503 | SR 0987 ≥98% | 303126-97-8 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 19503 | SR 0987 ≥98% | 303126-97-8 | 10mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 19503 | SR 0987 ≥98% | 303126-97-8 | 25mg | $236 | 2024-03-01 | Buy |
| Tocris | 5868 | SR0987 ≥98%(HPLC) | 303126-97-8 | 50 | $704 | 2021-12-16 | Buy |
SR 0987 Chemical Properties,Uses,Production
Description
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.
Uses
SR 0987 is a RORγt agonist.
storage
Store at +4°C
References
1) Chang?et al.?(2016),?Synthetic RORγt Agonists Enhance Protective Immunity;?ACS Chem. Biol.?11?1012
SR 0987 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 49)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27313 | 60 |
303126-97-8(SR 0987)Related Search:
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SR 0987
2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
SR 0987;SR-0987;SR0987;303126-97-8
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
SR0987 >=98% (HPLC)
SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor
303126-97-8
C16H10ClF6NO2
API