ChemicalBook >> CAS DataBase List >>PF-9366
PF-9366
- CAS No.
- 72882-78-1
- Chemical Name:
- PF-9366
- Synonyms
- CS-2703;PF-9366;PF 9366 NEW;PF-9366; PF 9366; PF9366;72882-78-1;PF-9366,inhibit,PF9366,PF 9366,Inhibitor;[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-;2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
- CBNumber:
- CB13375661
- Molecular Formula:
- C20H19ClN4
- Molecular Weight:
- 350.84
- MDL Number:
- MFCD31630724
- MOL File:
- 72882-78-1.mol
Last updated:2024-11-19 23:02:33
| Melting point | 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 20 mg/ml). |
| pka | 8.75±0.28(Predicted) |
| form | solid |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
PF-9366 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30782 | PF-9366 | 72882-78-1 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 30782 | PF-9366 | 72882-78-1 | 25mg | $317 | 2024-03-01 | Buy |
| Cayman Chemical | 30782 | PF-9366 | 72882-78-1 | 10mg | $152 | 2024-03-01 | Buy |
| TRC | P294108 | PF-9366 | 72882-78-1 | 10mg | $825 | 2021-12-16 | Buy |
| AK Scientific | 9179CT | CID12612431 | 72882-78-1 | 50mg | $640 | 2021-12-16 | Buy |
PF-9366 Chemical Properties,Uses,Production
Description
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
Uses
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
References
1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785
Synthesis of PF-9366 from N,N,N',N'-TETRAMETHYLDIAMINOMETHANE and Acetyl chloride and [1,2,4]Triazolo[4,3-a]quinoline, 7-chloro-1-methyl-5-phenyl-
PF-9366 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 56)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30239 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
72882-78-1(PF-9366)Related Search:
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1of4
PF-9366
CS-2703
PF-9366; PF 9366; PF9366;72882-78-1
PF 9366 NEW
[1,2,4]Triazolo[4,3-a]quinoline-1-ethanamine, 7-chloro-N,N-dimethyl-5-phenyl-
2-(7-Chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
PF-9366,inhibit,PF9366,PF 9366,Inhibitor
72882-78-1
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