Colistin sodium methanesulfonate

Colistin sodium methanesulfonate Properties

Melting point	>228°C (dec.)
storage temp.	2-8°C
solubility	H2O: soluble10mg/mL
form	powder
color	white to faintly beige
PH	6-8 (10mg/mL in H2O)
Water Solubility	Freely soluble in water
Merck	13,2503
CAS DataBase Reference	8068-28-8
FDA UNII	XW0E5YS77G
EPA Substance Registry System	Colistimethate sodium (8068-28-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H362-H361
Precautionary statements	P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
RIDADR	3249
WGK Germany	2
RTECS	GH1650000
F	3
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	2941906000
Toxicity	LD50 i.v. in mice: >550 mg/kg (Barnett)

Colistin sodium methanesulfonate price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001887	E1 Colistimethate sodium for peak identification European Pharmacopoeia (EP) Reference Standard	8068-28-8	Y0001887	$153	2024-03-01	Buy
Sigma-Aldrich	Y0001886	E2 Colistimethate sodium for peak identification European Pharmacopoeia (EP) Reference Standard	8068-28-8	Y0001886	$153	2024-03-01	Buy
Sigma-Aldrich	C1511	Colistin sodium methanesulfonate ~11,500?U/mg	8068-28-8	10000000units	$246	2024-03-01	Buy
Sigma-Aldrich	C1511	Colistin sodium methanesulfonate ~11,500?U/mg	8068-28-8	100000000units	$1530	2024-03-01	Buy
Sigma-Aldrich	1147009	Colistimethate sodium	8068-28-8	200mg	$447	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0001887	Y0001887	$153	Buy
Y0001886	Y0001886	$153	Buy
C1511	10000000units	$246	Buy
C1511	100000000units	$1530	Buy
1147009	200mg	$447	Buy

Colistin sodium methanesulfonate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, hygroscopic powder.

Uses

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.

Definition

ChEBI: A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative, it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

brand name

Coly-Mycin (Monarch).

General Description

Two forms of colistins, colistin sulfate and colistin methanesulfonate sodium (Colistin sodium methanesulfonate)(CMS-Na), are commercially available. CMS-Na is administered intravenously, and CMS, the free base of CMS-Na consisting of CMS A and CMS B, is hydrolyzed in vivo to form active colistin A and colistin B6 . Colistin first became available for clinical use in 1959 and has been used worldwide for several decades[5].

Biological Activity

colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin e), which is an antibiotic with effect against most gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. colistin is produced by certain strains of the bacteria paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.in vitro: studying the time-kill kinetics of colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean auc0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. besides, by investigation among mucoid and nonmucoid strains of pseudomonas aeruginosa isolated from patients with cystic fibrosis, colistin methanesulfonate was found to require a concentration of 16 times the mic to achieve complete killing within 24 h [3].

Pharmacokinetics

Colistin is administered intravenously as the non-active prodrug, colistin methanesulfonate sodium (CMS). Colistin methanesulfonate sodium (Colistin sodium methanesulfonate) is eliminated mainly by renal clearance. If CMS is cleared rapidly by the kidney, less CMS is converted to colistin resulted in low colistin that could lead to ineffective antibacterial therapy. In patients with normal renal function (1–2 MIU of CMS), approximately 30–60% of a dose of CMS is converted to colistin. The renal clearance of CMS is much more efficient than the conversion of CMS to colistin. Therefore, to achieve a targeted concentration of >2 mg/L, patients must receive four to five times the amount of CMS. There was wide variability of colistin Cmax values (0.6–8.7 mg/L) in plasma among single-dose studies receiving 2–3 MIU of CMS in critically ill patients with preserved renal function. Almost none of the ICU patients achieved a colistin concentration of more than 2 mg/L in the Plachouras et al. and Mohamed et al. studies[4].

Safety Profile

Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO

References

[1] Yusuf, Wan Nazirah Wan . "Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review." Pharmaceuticals 14(2021).

References

[1] nation r l, li j. colistin in the 21st century.[j]. current opinion in infectious diseases, 2009, 22(6): 535-543.
[2] bergen p j, li j, rayner c r, et al. colistin methanesulfonate is an inactive prodrug of colistin against pseudomonas aeruginosa.[j]. antimicrobial agents and chemotherapy, 2006, 50(6): 1953-1958.
[3] li j, turnidge j d, milne r w, et al. in vitro pharmacodynamic properties of colistin and colistin methanesulfonate against pseudomonas aeruginosaisolates from patients with cystic fibrosis[j]. antimicrobial agents and chemotherapy, 2001, 45(3): 781-785.
[4] Yusuf, Wan Nazirah Wan . "Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review.&quotPharmaceuticals14(2021).
[5] Mizuyachi, Kaori , et al. "Safety and pharmacokinetic evaluation of intravenous colistin methanesulfonate sodium in Japanese healthy male subjects."Current Medical Research and Opinion27.12(2011):2261-2270.

Colistin sodium methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

Colistin sodium methanesulfonate Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1004	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	8946	55
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	3942	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3096	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Qiuxian Baitai New Material Co., LTD	58
Xi'an MC Biotech, Co., Ltd.	58
Dorne Chemical Technology co. LTD	58

View Lastest Price from Colistin sodium methanesulfonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-26	Colistimethate Sodium 8068-28-8	US $0.00 / Kg/Bag	2Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2024-12-13	COLISTIN METHANESULFONATE SODIUM SALT 8068-28-8	US $0.00 / KG/Tin	5KG	≥390μg/mg; USP	100KG/Month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-19	Colistin methanesulfonate sodium salt 8068-28-8	US $41.00 / mg		≥98%	10g	TargetMol Chemicals Inc.

Colistimethate Sodium
8068-28-8
US $0.00 / Kg/Bag
99% up, High Density
Sinoway Industrial co., ltd.

COLISTIN METHANESULFONATE SODIUM SALT
8068-28-8
US $0.00 / KG/Tin
≥390μg/mg; USP
WUHAN FORTUNA CHEMICAL CO., LTD

Colistin methanesulfonate sodium salt
8068-28-8
US $41.00 / mg
≥98%
TargetMol Chemicals Inc.

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COLIMYCIN SODIUM METHANESULFONATE COLISTIN METHANESULFONATE SODIUM SALT (METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT POLYMYXIN E SODIUM METHANESULFONATE colimycinm colistinat colistinmethanesulfonicacid,sodiumsalt colistinsulfomethat colistinsulfomethate colistinsulfomethatesodium colistrimethatesodium coly-mycininjectable colymycinm coly-mycinmparenteral pentasodiumcolistinmethanesulfonate sodiumcolistimethate sodiumcolistinemethanesulfonate sodiumcolistinmethanesulfonate w1929 COLISTIN METHANESULFONATE SODIUM COLISTIN SODIUM METHANESULFONATE FROM BA CILLUS COLISTINUS ColistimethaleSodium COLISTINSULPHOMETHATESODIUM Coly-mycin M (TN) COLISTIN METHANESULFATE SODIUM USP Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate colistinmethanesulfonicacid,sod pentasodium [[4-[[2-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-diisobutyl-2,5,8,11,14,17,20-heptaketo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]carbamoyl]-3-(sulfonatomethylamino)propyl]carbamoyl]propyl]amino]-4-keto-3-(6-methyloctanoylamino)butyl]amino]methanesulfonate pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxo-butan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxo-butyl]amino]methanesulfonate pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxobutyl]amino]methanesulfonate ColistiMethate SodiuM, USP Colistimethate Sodium (200 mg) Promixi Colistin, methyl sulfate, sodium salt Methanesulfonic acid derivative of Polymyxin E E1 Colistimethate sodium for peak identification Sodium Colistin Methanesulfonate (Technical Grade) Colistimethate sodium for peak identification (Y0001888) Colistimethate sodiumQ: What is Colistimethate sodium Q: What is the CAS Number of Colistimethate sodium Q: What is the storage condition of Colistimethate sodium Q: What are the applications of Colistimethate sodium Colistimethate Sodium (1147009) COLISTIN SODIUM METHANESULFONATE Colistin Methanesulfonate Colistimethate sodium CRS 3a,6-Dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione colistimethatesodiumispreparedfromcolistinbytheactionofformaldehydeandsodiumhydrogensulfitetoformamixtureofditopentabis-sulfomethylatedprimaryaminederivatives,mainlypolymyxinse1ande2. Semi-syntheticproductderivedfromafermentationproduct Sodium myxin methanesulfonate 8068-28-8 C58H115N16Na5O28S5 C57H102N16Na5O28S5R C58H105N16O28S5Na5 C58H105N16Na5O25S5 C58H105N16O28S55Na Antibiotics Antibiotics A-F Antibiotics A to Z BioChemical COLOMYCIN