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Fmoc-Lys(Boc)-OH

Fmoc-Lys(Boc)-OH structure

CAS No.: 71989-26-9

Chemical Name:: Fmoc-Lys(Boc)-OH

Synonyms: FMOC-LYS(BOC)-OH;FMOC-LYS(BOC);FMOC-L-LYS(BOC)-OH;FMOC-D-LYS(BOC);fmoc-lys(boc)-o;FMOC-L-LYS(BOC);Fmoc-L-Lysine(Boc)-OH;Nα-Fmoc-Nε-Boc-L-lysine;Nα-Fmoc-Nε-Boc-L-lysine;N6-(TERT-BUTOXYCARBONYL)-N2-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LYSINE

CBNumber:: CB1451227

Molecular Formula:: C26H32N2O6

Molecular Weight:: 468.54

MDL Number:: MFCD00037138

MOL File:: 71989-26-9.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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Fmoc-Lys(Boc)-OH Properties

Melting point	130-135 °C (dec.)
alpha	-12 º (c=2,DMF 24 ºC)
Boiling point	570.69°C (rough estimate)
Density	1.2301 (rough estimate)
refractive index	-12 ° (C=1, DMF)
storage temp.	Store below +30°C.
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	3.88±0.21(Predicted)
form	Powder
color	White
optical activity	[α]20/D 12±1°, c = 1% in DMF
Water Solubility	Slightly soluble in water.
BRN	4217767
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	UMRUUWFGLGNQLI-QFIPXVFZSA-N
CAS DataBase Reference	71989-26-9(CAS DataBase Reference)
FDA 21 CFR	582.5411

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes

Safety Statements

24/25-36/37/39-27-26

WGK Germany

HS Code

29224999

NFPA 704

	0
1		0

Fmoc-Lys(Boc)-OH price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52012	Fmoc-Lys(Boc)-OH Novabiochem?	71989-26-9	25g	$72.8	2024-03-01	Buy
Sigma-Aldrich	8.52012	Fmoc-Lys(Boc)-OH Novabiochem?	71989-26-9	100g	$183	2024-03-01	Buy
Sigma-Aldrich	8.52012	Fmoc-Lys(Boc)-OH Novabiochem?	71989-26-9	250g	$365	2024-03-01	Buy
Sigma-Aldrich	8.52012	Fmoc-Lys(Boc)-OH Novabiochem?	71989-26-9	1kg	$1370	2024-03-01	Buy
Sigma-Aldrich	47624	Fmoc-Lys(Boc)-OH ≥98.0% (HPLC)	71989-26-9	1G	$28.5	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.52012	25g	$72.8	Buy
8.52012	100g	$183	Buy
8.52012	250g	$365	Buy
8.52012	1kg	$1370	Buy
47624	1G	$28.5	Buy

Fmoc-Lys(Boc)-OH Chemical Properties,Uses,Production

Description

Fmoc-Lys(Boc)-OH (Na-Fmoc-Ne-Boc-L-lysine) has emerged as the standard Fmoc-Lys derivative used in peptide synthesis. The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin. It could self-assemble to sphere like morphology in all conditions irrespective of concentration and heating. To prepare the FAPI-04 dimer complex, this compound could used as a linker to conjugate two FAPI-04 structures by an amide reaction. After further modification, the product can perform cancer theranostics[1-2].

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-Lys(Boc)-OH can be used for:

The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as ¹⁹F NMR based screening tool.

Uses

It is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use.

References

[1] Gour N, et al. Controlled aggregation properties of modified single amino acids. ChemRxiv, 2021; 46.
[2] Zhong X, et al. Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics. Molecular Pharmaceutics, 2023; 20: 2402–2414.

Fmoc-Lys(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

FMOC-LYS(TEOC)-OH Fmoc-L-HomoArg(Pbf)-OH FMOC-LYS(BIOTIN)-OH Fmoc-L-Lys(Dde)-OH Copper Peptide

(S)-2-(allyloxycarbonylaMino)-6-(tert-butoxycarbonylaMino)hexanoic acid FMOC-LYS(BOC)-OPFP

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Fmoc-Lys(Boc)-OH Suppliers

Global( 534)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Ningxia LabsChem Co., Ltd.	0952-9294929 +8613895679378	48472788@qq.com	China	352	58
Chengdu Baishixing Science and Technology Industry Co.,Ltd	+86-15008457246 +86-15008457246	yuki@cd-bsx.com	China	53	58
Chengdu ZY Biochemical Technology Co., Ltd.	+86-86-2888626688 +8618980008884	xuehaiying@zybiochem.com	China	125	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	902	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-028-64841719 +8617390183901	daisy@enlaibio.com	China	1106	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20285	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18767	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55

Supplier	Advantage
Ningxia LabsChem Co., Ltd.	58
Chengdu Baishixing Science and Technology Industry Co.,Ltd	58
Chengdu ZY Biochemical Technology Co., Ltd.	58
Wuhan senwayer century chemical Co.,Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from Fmoc-Lys(Boc)-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-03	Fmoc-L-Lys(Boc)-OH 71989-26-9	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-12-03	N-Fmoc-N'-Boc-L-Lysine 71989-26-9	US $5.00 / kg	1kg	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2024-11-29	N-alpha-FMOC-Nepsilon-BOC-L-Lysine 71989-26-9	US $0.00-0.00 / Kg/Drum	1KG	99.5%min	500KGS	WUHAN FORTUNA CHEMICAL CO., LTD

Fmoc-L-Lys(Boc)-OH
71989-26-9
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Fmoc-N'-Boc-L-Lysine
71989-26-9
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

N-alpha-FMOC-Nepsilon-BOC-L-Lysine
71989-26-9
US $0.00-0.00 / Kg/Drum
99.5%min
WUHAN FORTUNA CHEMICAL CO., LTD

Fmoc-Lys(Boc)-OH Spectrum

N-alpha-FMOC-Nepsilon-BOC-L-Lysine(71989-26-9)¹HNMR N-alpha-FMOC-Nepsilon-BOC-L-Lysine(71989-26-9)FT-IR

71989-26-9(Fmoc-Lys(Boc)-OH)Related Search:

Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate N-(9-Fluorenylmethoxycarbonyloxy)succinimide L-Lysine AC-HIS-OH H2O

Cbz-beta-Amino-L-alanine DI-TERT-BUTYL ETHER FMOC-Ala-OH FMOC-S-trityl-L-cysteine Fmoc-Asp(OtBu)-OH

FMOC-L-Valine FMOC-L-Methionine FMOC-N-METHYL-TRANEXAMIC ACID Fmoc-L-Tyr(propargyl)-OH Fmoc-Gly-OH

FMOC-O-tert-Butyl-L-serine Fmoc-Asn(Trt)-OH FMOC-TRANEXAMIC ACID

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N^α-FMoc-N^ε-Boc-L-lysine N^e-Boc-N^a-FMoc-L-lysine, 98% ALPHA-FMOC-EPSILON-BOC-LYSINE FMOC-D-LYSINE(BOC)-OH FMOC-L-LYS(TBOC)-OH FMOC-L-LYSINE(BOC) FMOC-L-LYSINE (TBOC) FMOC-N-EPSILON-BOC-D-LYSINE FMOC-N-EPSILON-BOC-L-LYSINE FMOC-LYSINE(BOC)-OH Fmoc-(Boc)lysine Fmoc-Lys(Boc)-OH (N-Alpha-Fmoc-N-Epsilon-Boc-L-Lysine) N-alpha-FMOC-Nepsilo Nalpha-FMOC-Nepsilon-BOC-L-Lysine,99% L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC Nepsilon-Boc-Nalpha-Fmoc-L-lysine Fmoc-Lys(Boc)-OH Fmoc-Iys(Boc)-OH FMoc-Lys(Boc)-OH >=98.0% (HPLC) Fmoc-Lys(Boc)-OH(CAS:71989-26-9) L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (13C6 L-LYSINE-ALPHA-N-FMOC, EPSILON-N-T-BOC (1-13C) Nε-(tert-Butoxycarbonyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Nα-Fmoc-Nε-Boc-L-lysine≥ 99.5% (HPLC, Chiral purity) N-α-FMOC-N-&epsi:-BOC-L-lysine N-ALPHA-FMOC-N-EPSILON-BOC-D-LYSINE N-ALPHA-FMOC-N-EPSILON-BOC-L-LYSINE N-ALPHA-FMOC-N-EPSILON-T-BOC-D-LYSINE N-ALPHA-FMOC-N-EPSILON-T-BOC-L-LYSINE N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-D-LYSINE N-ALPHA-FMOC-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE N-ALPHA-FMOC-N-EPSILON-TERT-BOC-D-LYSINE N-ALPHA-FMOC-N-EPSILON-TERT-BOC-L-LYSINE N-ALPHA-FMOC-T-BOC-L-LYS N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE NEPSILON-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L- lysine FMOC-N-(EPSILON)-BOC-L-LYSINE (FMOC-L-LYS(BOC)-OH) FMOC-N-E-BOC-L-LYSINE N-α-Fmoc-N-ε-t.-Boc-L-lysine L-Lysine-UL-13C6, 15N2-α-N-FMOC, ε-N-t-BOC L-Lysine-1-13C-α-N-FMOC, ε-N-t-BOC NA-FMOC-N-E-BOC-L-LYSINE N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-EPSILON-T-BUTYLOXYCARBONYL-L-LYSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-(TERT-BUTOXYCARBONYL)-L-LYSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-T-BUTOXYCARBONYL-L-LYSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-T-BUTOXYCARBONYL-D-LYSINE N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-EPSILON-T-BUTYLOXYCARBONYL-D-LYSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-T-BUTYL-OXYCARBONYL-D-LYSINE NALPHA-9-FLUORENYLMETHYLOXYCARBONYL-NEPSILON-TERT-BUTOXYCARBONYL-L-LYSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-TERT-BUTYLOXYCARBONYL-L-LYSINE N(ALPHA)-(9-FLUROENYLMETHOXYCARBONYL)-N& NA-FMOC-N-EPSILON-T-BOC-L-LYSINE FMOC-LYS(BOC)-OH 98+% L-Lysine-1-13C-alpha-N-FMOC, epsilon-N-t-BOC L-Lysine-UL-13C6, 15N2-alpha-N-FMOC, epsilon-N-t-BOC nepsilon-(tert-butoxycarbonyl)-nalpha-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-lysine nepsilon-boc-nalpha-fmoc-l-lysine Nalpha-9-Fluorenylmethyloxycarbonyl-Ne-t-butoxycarbonyl-L-lysine