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PD184352

CAS No.
212631-79-3
Chemical Name:
PD184352
Synonyms
CS-333;Ci-1040;PD184352;PD 184352, >=98%;CI-1040, PD-184352;PD184352 USP/EP/BP;PD 184352;CI-1040;PD-184352;CI1040;PD-184352; CI 1040 (PD184352);2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
CBNumber:
CB1500875
Molecular Formula:
C17H14ClF2IN2O2
Molecular Weight:
478.66
MDL Number:
MFCD02683961
MOL File:
212631-79-3.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

PD184352 Properties

Melting point 166-169°C
Density 1.747±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥30mg/mL
pka -5.58±0.50(Predicted)
form powder
color white to tan
FDA UNII R3K9Y00J04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  2924297099

PD184352 price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0181 PD 184352 ≥98% (HPLC) 212631-79-3 5mg $129 2024-03-01 Buy
Sigma-Aldrich PZ0181 PD 184352 ≥98% (HPLC) 212631-79-3 25mg $516 2024-03-01 Buy
TCI Chemical P2174 PD 184352 212631-79-3 25MG $243 2024-03-01 Buy
TCI Chemical P2174 PD 184352 212631-79-3 100MG $726 2024-03-01 Buy
Cayman Chemical 11580 CI-1040 ≥98% 212631-79-3 5mg $81 2024-03-01 Buy
Product number Packaging Price Buy
PZ0181 5mg $129 Buy
PZ0181 25mg $516 Buy
P2174 25MG $243 Buy
P2174 100MG $726 Buy
11580 5mg $81 Buy

PD184352 Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pale Beige Solid

Uses

An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Potent MEK inhibitor.

Definition

ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.

Biological Activity

pd184352 (also known as ci-1040), a benzhydroxamate derivative, is a potent and highly selective mek1/2, two members of the family of mapkks, inhibitor that inhibits purified mek1 with ic50 of 17 nm in a non-atp and non-erk1/2 competitive manner [1].pd184352 binds to a hydrophobic pocket, which is located in a region with low sequence homology to other kinases, adjacent to the mg-atp binding site of mek1 and mek2 inducing a conformational change in un-phosphorylated mek1/2 and hence inactivating the un-phosphorylated mek1/2 [1].pd184352 has been found to be actively against tumors, where it inhibits the growth of colon carcinomas in mouse xenograft models [1].

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

storage

Store at +4°C

References

[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8.

PD184352 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 146)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22785 58

View Lastest Price from PD184352 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CI-1040 pictures 2024-11-19 CI-1040
212631-79-3
US $48.00-150.00 / mg 99.1% 10g TargetMol Chemicals Inc.
PD184352 pictures 2019-07-06 PD184352
212631-79-3
US $8.00 / kg 1kg 99% 10tons Career Henan Chemical Co
  • CI-1040 pictures
  • CI-1040
    212631-79-3
  • US $48.00-150.00 / mg
  • 99.1%
  • TargetMol Chemicals Inc.
  • PD184352 pictures
  • PD184352
    212631-79-3
  • US $8.00 / kg
  • 99%
  • Career Henan Chemical Co

PD184352 Spectrum

PD184352 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide 2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE 2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro- Ci-1040 CI-1040, PD-184352 3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide PD184352 CI-10402-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide PD 184352, >=98% CI1040;PD-184352; CI 1040 (PD184352) CS-333 PD 184352;CI-1040;PD-184352 PD184352 USP/EP/BP 212631-79-3 C17H14ClF2IN2O2 Anti-cancer&immunity MAPK Pfizer compounds Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals Inhibitors All Inhibitors