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Ethyl 2-chloropyrimidine-5-carboxylate

Ethyl 2-chloropyrimidine-5-carboxylate structure

CAS No.: 89793-12-4

Chemical Name:: Ethyl 2-chloropyrimidine-5-carboxylate

Synonyms: EOS-60350;ETHYL2-CHLOROPYRIMI;2-chloro-pyriMidine-5-carboxylate;Ethyl 2-Chlorpyrimidine-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)pyrimidine;ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloropyrimidine-5-carboxylate ,97%;2-chloro-pyrimidine-5-carboxylic acid ethyl ester;PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester;5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester

CBNumber:: CB1547225

Molecular Formula:: C7H7ClN2O2

Molecular Weight:: 186.6

MDL Number:: MFCD09863164

MOL File:: 89793-12-4.mol

Last updated:2024-07-02 09:57:38

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Ethyl 2-chloropyrimidine-5-carboxylate Properties

Melting point	52-60℃
Boiling point	80℃/760mm
Density	1.311±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	soluble in Methanol
pka	-3.05±0.22(Predicted)
form	Solid
color	White to Light yellow
InChI	InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
InChIKey	IEMKQRSOAOPKRJ-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference	89793-12-4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

20/21/22

Safety Statements

36/37

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

Ethyl 2-chloropyrimidine-5-carboxylate price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1250	Ethyl 2-Chloropyrimidine-5-carboxylate >98.0%(GC)	89793-12-4	1g	$71	2024-03-01	Buy
Alfa Aesar	H64914	Ethyl 2-chloropyrimidine-5-carboxylate, 97%	89793-12-4	1g	$95.65	2024-03-01	Buy
Alfa Aesar	H64914	Ethyl 2-chloropyrimidine-5-carboxylate, 97%	89793-12-4	5g	$364.65	2024-03-01	Buy
Alfa Aesar	H64914	Ethyl 2-chloropyrimidine-5-carboxylate, 97%	89793-12-4	250mg	$32.1	2021-12-16	Buy
TRC	E678415	Ethyl2-Chlorpyrimidine-5-carboxylate	89793-12-4	10g	$825	2021-12-16	Buy

Product number	Packaging	Price	Buy
E1250	1g	$71	Buy
H64914	1g	$95.65	Buy
H64914	5g	$364.65	Buy
H64914	250mg	$32.1	Buy
E678415	10g	$825	Buy

Ethyl 2-chloropyrimidine-5-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to light yellow liquid

Uses

Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.

Synthesis

A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).

Ethyl 2-chloropyrimidine-5-carboxylate synthesis

Synthesis of Ethyl 2-chloropyrimidine-5-carboxylate from 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester

Ethyl 2-chloropyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl potassium malonate Ethanol Ethyl 3-ethoxypropionate N,N-Dimethylformamide Ethyl formate

Toluene Sodium Phosphorus oxychloride Urea N,N-Dimethylaniline

Hydrochloric acid Government regulation Acetic acid Dimethyl sulfate

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Preparation Products

2-Chloropyrimidine-5-carbonitrile (2-Pyrrolidin-1-ylpyrimidin-5-yl)methanol

Ethyl 2-chloropyrimidine-5-carboxylate Suppliers

Global( 251)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Fred Technology Co., Ltd	+86-25-84696168 +86-15380713688	Austin@fredbio.com	China	2428	58
Lianhe Aigen Pharmatech Co.,Ltd.	+undefined+undefined18918657159	sales-Aigen@lianhetech.com	China	314	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58

Supplier	Advantage
Nanjing Fred Technology Co., Ltd	58
Lianhe Aigen Pharmatech Co.,Ltd.	58
Finetech Industry Limited	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58

View Lastest Price from Ethyl 2-chloropyrimidine-5-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Ethyl 2-chloropyrimidine-5-carboxylate 89793-12-4	US $0.00 / kg	1kg	99%HPLC;99%GC	1ton	Nanjing Fred Technology Co., Ltd
2021-07-02	ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-05-15	ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE 89793-12-4	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

Ethyl 2-chloropyrimidine-5-carboxylate
89793-12-4
US $0.00 / kg
99%HPLC;99%GC
Nanjing Fred Technology Co., Ltd

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE
89793-12-4
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Ethyl 2-chloropyrimidine-5-carboxylate Spectrum

ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)¹HNMR ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE(89793-12-4)FT-IR

89793-12-4(Ethyl 2-chloropyrimidine-5-carboxylate)Related Search:

4,6-Dihydroxypyrimidine 2,5-PYRIDINEDICARBOXYLIC ACID 2-Chloropyrimidine 2-Chloropyrimidine-5-carboxylic acid ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate

BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate Ethyl 2-chloropyrimidine-5-carboxylate ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE

CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate

ethyl 2,4-dichloropyrimidine-5-carboxylate

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Ethyl 2-chloropyrimidine-5-carboxylate ,97% 2-chloro-pyrimidine-5-carboxylic acid ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine 5-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester ETHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE PyriMidin-5-carboxylic acid 2-chloro-, ethyl ester 2-Chloro-5-(ethoxycarbonyl)pyrimidine, 2-Chloro-5-(ethoxycarbonyl)-1,3-diazine Ethyl 2-Chlorpyrimidine-5-carboxylate 2-chloro-pyriMidine-5-carboxylate ETHYL2-CHLOROPYRIMI EOS-60350 5-Pyrimidinecarboxylic acid, 2-chloro-, ethyl ester (7CI, 9CI, ACI) 2-chloro-5-Pyrimidinecarboxylic acid ethyl ester (7CI 9CI ACI) 89793-12-4 Heterocycle-Pyrimidine series