에틸2-클로로피리미딘-5-카르복실레이트
|
|
에틸2-클로로피리미딘-5-카르복실레이트 속성
- 녹는점
- 52-60℃
- 끓는 점
- 80℃/760mm
- 밀도
- 1.311±0.06 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 용해도
- 메탄올에 용해됨
- 산도 계수 (pKa)
- -3.05±0.22(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 밝은 노란색
- InChI
- InChI=1S/C7H7ClN2O2/c1-2-12-6(11)5-3-9-7(8)10-4-5/h3-4H,2H2,1H3
- InChIKey
- IEMKQRSOAOPKRJ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C(OCC)=O)C=N1
- CAS 데이터베이스
- 89793-12-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
에틸2-클로로피리미딘-5-카르복실레이트 C화학적 특성, 용도, 생산
화학적 성질
White to light yellow liquid용도
Ethyl 2-chloropyrimidine-5-carboxylate is used in the synthesis of Retinoid x receptor agonists (RXR) that are used in the treatment of cancers.Synthesis
A mixture of 1,2-Dihydro-2-oxo-5-pyrimidinecarboxylic acid ethyl ester (3.60 g, 21 mmol), phosphorus oxychloride (25 mL), and N, N-dimethylaniline (2.5 mL) was heated to reflux for 1.5 h. After removal of the solvent, ice water (10 mL) was added to the residue. The mixture was added to 2 N NaOH (90 ml) and extracted with EtOAc. After work, the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 5 per cent v/v) to give the product Ethyl 2-chloropyrimidine-5-carboxylate (1.20 g, 30 per cent).에틸2-클로로피리미딘-5-카르복실레이트 준비 용품 및 원자재
원자재
Ethyl potassium malonate
에틸알코올
에폭시프로피온산에틸에스테르
N,N-다이메틸폼아마이드
포름산에틸
톨루엔
나트륨
포스포러스옥시클로라이드
요소
N,N-디메틸아닐린
염산
브롬
아세트산(빙초산)
디메틸설페이트
준비 용품
에틸2-클로로피리미딘-5-카르복실레이트 공급 업체
글로벌( 251)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 |
Austin@fredbio.com | China | 2428 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +undefined+undefined18918657159 |
sales-Aigen@lianhetech.com | China | 314 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9639 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18779 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29884 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10310 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 |
info@habotech.com | CHINA | 933 | 58 |
에틸2-클로로피리미딘-5-카르복실레이트 관련 검색:
4,6-Dihydroxypyrimidine
2,5-PYRIDINEDICARBOXYLIC ACID
2-Chloropyrimidine
2-Chloropyrimidine-5-carboxylic acid
ethyl 2-chloro-4-(1-methylethyl)pyrimidine-5-carboxylate
BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
ethyl 2-chloro-4-ethylpyrimidine-5-carboxylate
Ethyl 2-chloropyrimidine-5-carboxylate
ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE
ETHYL-2-CHLORO-4-METHYL-5-PYRIMIDINECARBOXYLATE
CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
ETHYL 2-CHLORO-4-(N-ETHOXYCABONYLETHYL-N-ETHYLAMINO) PYRIMIDINE-5-CARBOXYLATE
ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
ethyl 4-tert-butyl-2-chloropyrimidine-5-carboxylate
ethyl 2,4-dichloropyrimidine-5-carboxylate