SB 203580 | 152121-47-6

SB 203580 Properties

Melting point	144-146
Boiling point	615.6±55.0 °C(Predicted)
Density	1.4
storage temp.	-20°C
solubility	DMSO: 50 mg/mL
form	solid
pka	9.60±0.10(Predicted)
color	white to off-white
Stability	-200C
InChIKey	CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS DataBase Reference	152121-47-6(CAS DataBase Reference)
FDA UNII	OU13V1EYWQ

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P264-P270-P280-P301+P312-P305+P351+P338-P501

Hazard Codes

Xn

Risk Statements

22-41

Safety Statements

26-39

WGK Germany

3

HS Code

29333990

NFPA 704

	0
3		0

SB 203580 price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	559389	SB 203580	152121-47-6	1mg	$172	2024-03-01	Buy
Sigma-Aldrich	559389	SB 203580	152121-47-6	5mg	$318	2024-03-01	Buy
TCI Chemical	F0864	SB 203580	152121-47-6	25MG	$105	2024-03-01	Buy
TCI Chemical	F0864	SB 203580	152121-47-6	100MG	$324	2024-03-01	Buy
Alfa Aesar	J61482	SB 203580, 98%	152121-47-6	25mg	$156	2023-06-20	Buy

Product number	Packaging	Price	Buy
559389	1mg	$172	Buy
559389	5mg	$318	Buy
F0864	25MG	$105	Buy
F0864	100MG	$324	Buy
J61482	25mg	$156	Buy

SB 203580 Chemical Properties,Uses,Production

Description

SB 203580 (152121-47-6) is a potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively.1 No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM.2?A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function.3

Chemical Properties

White to Off-White Solid

Uses

MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.¹⁶ It was used to inhibit MAPK signaling in mouse cortical neurons¹⁷ and human hepatocellular carcinoma cell lines.¹⁸

Uses

A p38 MAPK inhibitor with an IC50 range of 0.3-0.5 μM and blocks PKB phosphorylation with an IC50 range of 3-5 μM.

Uses

A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase

Definition

ChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.

General Description

Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 μM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC₅₀ = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.

Biological Activity

Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Biochem/physiol Actions

SB 203580 is a pyridinyl imidazole that suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein (HSP) 27 in response to IL-1, cellular stresses and bacterial endotoxin in vivo. It does not inhibit JNK or p42 MAP kinase and therefore, is useful for studying the physiological roles and targets of p38 MAPK and MAPKAP kinase-2. It has been shown to induce the activation of the serine/threonine kinase Raf-1 and has been reported to inhibit cytokine production.

storage

+4°C (desiccate)

References

1) Cuenda et al. (1995), SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1; FEBS Lett., 364 229 2) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 3) Badger et al. (1996), Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function; Pharmacol. Exp. Ther. 279 1453

SB 203580 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 203580 Suppliers

Global( 228)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58

View Lastest Price from SB 203580 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-18	Adezmapimod 152121-47-6	US $30.00-64.00 / mg		99.87%	10g	TargetMol Chemicals Inc.
	2020-02-01	SB 203580 152121-47-6	US $3.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

Adezmapimod
152121-47-6
US $30.00-64.00 / mg
99.87%
TargetMol Chemicals Inc.

SB 203580
152121-47-6
US $3.00 / KG
98%
Career Henan Chemical Co

SB 203580 Spectrum

SB 203580(152121-47-6)¹HNMR

152121-47-6(SB 203580)Related Search:

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1,9-Pyrazoloanthrone PD 98059 SCH772984 LY 294002 HYDROCHLORIDE SB242235

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5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 431542 SB 202190

1of4

SB 203580 HYDROCHLORIDE SB 2035850 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL 4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine PB 203580 Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- 4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole SB 203580, >=98% 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB 203580 SB 203580 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole RWJ 64809 RWJ 64809; PB 203580 SB 203580 MAPK inhibitor (SB 203580) SB203580(RWJ 64809) SB 203580 - CAS 152121-47-6 - Calbiochem SB203580;SB 203580 SB203580 (RWJ 64809, PB 203580) CS-42 RWJ 64809;PB 203580;SB203580;SB-203580 SB SB SB 203580USP/EP/BP SB 203580 hydrochlor Adezmapimod SB 203580, ≥98% (HPLC) SB203850 Adezmapimod (SB203580 Inhibitor,SB-203580,PKBα,RWJ64809,inhibit,SAPK2a,GSK3β,Mitophagy,SB 203580,p38 MAPK,Mitochondrial Autophagy,Autophagy,LCK,RWJ-64809,Adezmapimod,SAPK2b,ATP-competitive 152121-47-6 C21H16FN3OSHCl C21H16FN3OS Cell Signaling and Neuroscience Cell Biology BioChemical Kinase/Phosphatase Biology MAPK-Activated Protein Kinase (MAPKAP Kinase) Serine/Threonine Kinase Inhibitors Inhibitors Selective inhibitor of p38 mitogen-activated protein kinase. inhibitor Signalling Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase pharmacetical