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NS-398

NS-398 structure

CAS No.: 123653-11-2

Chemical Name:: NS-398

Synonyms: NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;mitochondrial complex I inhibitor;mitochondrial complex III inhibitor

CBNumber:: CB1754593

Molecular Formula:: C13H18N2O5S

Molecular Weight:: 314.36

MDL Number:: MFCD00882995

MOL File:: 123653-11-2.mol

MSDS File:: SDS

Last updated:2024-11-19 15:53:33

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NS-398 Properties

Melting point	124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point	490.6±55.0 °C(Predicted)
Density	1.377±0.06 g/cm3(Predicted)
RTECS	PB0473500
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: >5 mg/mL
pka	6.33±0.10(Predicted)
form	solid
color	off-white
FDA UNII	9SP55KM2KS

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
HS Code	2935.90.9500

NS-398 price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N194	NS-398 ≥98% (HPLC), solid	123653-11-2	5mg	$110.4	2024-03-01	Buy
Sigma-Aldrich	349254	NS-398 A cell-permeable selective inhibitor of COX-2	123653-11-2	5mg	$216	2024-03-01	Buy
TCI Chemical	N1152	NS-398	123653-11-2	10MG	$113	2024-03-01	Buy
TCI Chemical	N1152	NS-398	123653-11-2	50MG	$411	2024-03-01	Buy
Alfa Aesar	J67313	NS-398, 98%	123653-11-2	5mg	$97.1	2023-06-20	Buy

Product number	Packaging	Price	Buy
N194	5mg	$110.4	Buy
349254	5mg	$216	Buy
N1152	10MG	$113	Buy
N1152	50MG	$411	Buy
J67313	5mg	$97.1	Buy

NS-398 Chemical Properties,Uses,Production

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Preparation Products And Raw materials

Raw materials

Preparation Products

Glyoxal Acrylamide

NS-398 Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18153	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	970	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22783	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58

View Lastest Price from NS-398 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	NS-398 123653-11-2	US $50.00 / kg	1kg	99%	1000	hebei hongtan Biotechnology Co., Ltd
2024-11-19	NS-398 123653-11-2	US $46.00-97.00 / mg		99.72%	10g	TargetMol Chemicals Inc.
2024-10-25	NS-398 123653-11-2	US $20.00-1.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.

NS-398
123653-11-2
US $50.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

NS-398
123653-11-2
US $46.00-97.00 / mg
99.72%
TargetMol Chemicals Inc.

NS-398
123653-11-2
US $20.00-1.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

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N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide) Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI)

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NS-398 N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE NS-398 98% N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide Taisho NS 398 CS-2231 NS-398 (NS 398 NS-398 - CAS 123653-11-2 - Calbiochem NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE NS NS Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]- NS-398 USP/EP/BP Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase mitochondrial complex I inhibitor mitochondrial complex III inhibitor glycolysis inhibitor 123653-11-2 123652-11-2 Cyclooxygenase (COX) Enzymes Cyclooxygenase Inhibitors Enzymes, Inhibitors, and Substrates Biochemicals and Reagents Cell Signaling Enzymes BioChemical Application Index Signalling Lipid signaling NF-κB Signaling