ChemicalBook >> CAS DataBase List >>[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate structure

CAS No.: 1469284-79-4

Chemical Name:: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

Synonyms: PF-06424439;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439

CBNumber:: CB22750426

Molecular Formula:: C23H30ClN7O4S

Molecular Weight:: 536.0468

MDL Number:: MFCD28137684

MOL File:: 1469284-79-4.mol

MSDS File:: SDS

Last updated:2024-11-19 15:53:33

Request For Quotation

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Properties

storage temp.	room temp
solubility	H2O: soluble10mg/mL, clear
form	powder
color	white to light brown

SAFETY

Risk and Safety Statements

WGK Germany	3

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0233	PF-06424439 ≥98% (HPLC)	1469284-79-4	5mg	$118	2024-03-01	Buy
Sigma-Aldrich	PZ0233	PF-06424439 ≥98% (HPLC)	1469284-79-4	25mg	$476	2024-03-01	Buy
Cayman Chemical	17680	PF-06424439 ≥98%	1469284-79-4	1mg	$44	2024-03-01	Buy
Cayman Chemical	17680	PF-06424439 ≥98%	1469284-79-4	10mg	$151	2024-03-01	Buy
Cayman Chemical	17680	PF-06424439 ≥98%	1469284-79-4	25mg	$321	2024-03-01	Buy

Product number	Packaging	Price	Buy
PZ0233	5mg	$118	Buy
PZ0233	25mg	$476	Buy
17680	1mg	$44	Buy
17680	10mg	$151	Buy
17680	25mg	$321	Buy

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Chemical Properties,Uses,Production

Description

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC₅₀ = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC₅₀s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.

Uses

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:

to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
to study its effects on HeLa cells
to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

storage

Desiccate at RT

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25003	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Guangzhou Isun Pharmaceutical Co., Ltd	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58

View Lastest Price from [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	PF-06424439 methanesulfonate 1469284-79-4	US $39.00-97.00 / mg		99.77%	10g	TargetMol Chemicals Inc.
	2024-11-19	PF-06424439 methanesulfonate 1469284-79-4	US $39.00-97.00 / mg		99.77%	10g	TargetMol Chemicals Inc.

PF-06424439 methanesulfonate
1469284-79-4
US $39.00-97.00 / mg
99.77%
TargetMol Chemicals Inc.

PF-06424439 methanesulfonate
1469284-79-4
US $39.00-97.00 / mg
99.77%
TargetMol Chemicals Inc.

1469284-79-4([(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate)Related Search:

PF-06700841 tosylate PF-06650833 PF-05089771 (tosylate) PF-06424439 PF-06447475

PF 3644022 PF 04995274 PF-3084014 PF 573228 PF-06882961

PF-5190457 PF-05212384 PF-04691502 1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]- PF 477736

1of3

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-06424439 >=98% (HPLC) PF-06424439 methanesulfonate PF-06424439 acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439 (R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate 1469284-79-4