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ChemicalBook >> CAS DataBase List >> [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate price.
  • $26 - $650
  • Product name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
  • CAS: 1469284-79-4
  • MF: C23H30ClN7O4S
  • MW: 536.0468
  • EINECS:
  • MDL Number:MFCD28137684
  • Synonyms:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;PF-06424439;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate
Price16 Properties Safety Information Description
16 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 5
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number2389EB
  • Product descriptionPF-06424439(methanesulfonate)
  • Packaging1mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17680
  • Product descriptionPF-06424439 ≥98%
  • Packaging500μg
  • Price$26
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17680
  • Product descriptionPF-06424439 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17680
  • Product descriptionPF-06424439 ≥98%
  • Packaging5mg
  • Price$87
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17680
  • Product descriptionPF-06424439 ≥98%
  • Packaging10mg
  • Price$151
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17680
  • Product descriptionPF-06424439 ≥98%
  • Packaging25mg
  • Price$321
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging25mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0068288
  • Product descriptionPF-06424439methanesulfonate 99.94%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0233
  • Product descriptionPF-06424439 ≥98% (HPLC)
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0233
  • Product descriptionPF-06424439 ≥98% (HPLC)
  • Packaging25mg
  • Price$476
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number6348
  • Product descriptionPF06424439 ≥98%(HPLC)
  • Packaging5
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP294143
  • Product descriptionPF06424439
  • Packaging25mg
  • Price$370
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2389EB PF-06424439(methanesulfonate) 1mg $166 2021-12-16 Buy
Cayman Chemical 17680 PF-06424439 ≥98% 500μg $26 2021-12-16 Buy
Cayman Chemical 17680 PF-06424439 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 17680 PF-06424439 ≥98% 5mg $87 2024-03-01 Buy
Cayman Chemical 17680 PF-06424439 ≥98% 10mg $151 2024-03-01 Buy
Cayman Chemical 17680 PF-06424439 ≥98% 25mg $321 2024-03-01 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 1mg $50 2021-12-16 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 5mg $70 2021-12-16 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 10mg $120 2021-12-16 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 25mg $250 2021-12-16 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 50mg $400 2021-12-16 Buy
ChemScene CS-0068288 PF-06424439methanesulfonate 99.94% 100mg $650 2021-12-16 Buy
Sigma-Aldrich PZ0233 PF-06424439 ≥98% (HPLC) 5mg $118 2024-03-01 Buy
Sigma-Aldrich PZ0233 PF-06424439 ≥98% (HPLC) 25mg $476 2024-03-01 Buy
Tocris 6348 PF06424439 ≥98%(HPLC) 5 $75 2021-12-16 Buy
TRC P294143 PF06424439 25mg $370 2021-12-16 Buy

Properties

storage temp. :room temp
solubility :H2O: soluble10mg/mL, clear
form :powder
color :white to light brown

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.

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