ChemicalBook >> CAS DataBase List >>AG 18
AG 18
- CAS No.
- 118409-57-7
- Chemical Name:
- AG 18
- Synonyms
- AG 18;TX 825;CS-931;RG-50810;RG 50858;AG18, >=98%;TYRPHOSTIN 23;TYRPHOSTIN A23;Tyrphostin AG 1;AG-18(RG-50810)
- CBNumber:
- CB2358507
- Molecular Formula:
- C10H6N2O2
- Molecular Weight:
- 186.17
- MDL Number:
- MFCD00133899
- MOL File:
- 118409-57-7.mol
- MSDS File:
- SDS
Last updated:2024-11-19 23:02:33
| Melting point | 225°C |
|---|---|
| Boiling point | 421.1±45.0 °C(Predicted) |
| Density | 1.428±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO, ethanol, or DMF |
| pka | 7.26±0.18(Predicted) |
| form | Yellow solid |
| color | Yellow |
| λmax | 464nm(DMSO)(lit.) |
| Stability | Store in refrigerator |
| FDA UNII | RV0GCD31OJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371-H373 |
| Precautionary statements | P501-P260-P270-P264-P308+P311-P405 |
| WGK Germany | 3 |
| HS Code | 2926.90.5050 |
AG 18 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T7165 | Tyrphostin 23 ≥98% | 118409-57-7 | 5mg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | 658395 | AG 18 A broad-spectrum protein tyrosine kinase inhibitor. | 118409-57-7 | 5mg | $85.2 | 2024-03-01 | Buy |
| TCI Chemical | T3503 | Tyrphostin A23 >98.0%(GC) | 118409-57-7 | 25mg | $128 | 2022-04-27 | Buy |
| TCI Chemical | T3503 | Tyrphostin A23 >98.0%(GC) | 118409-57-7 | 100mg | $280 | 2024-03-01 | Buy |
| Alfa Aesar | J60308 | Tyrphostin A23, 99% | 118409-57-7 | 5mg | $73.65 | 2024-03-01 | Buy |
AG 18 Chemical Properties,Uses,Production
Chemical Properties
Yellow Powder
Uses
A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
Uses
AG 18 inhibits EGFR with IC50 of 35 μM.
Definition
ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.
Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Biochem/physiol Actions
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
AG 18 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 164)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22784 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from AG 18 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Tyrphostin 23
118409-57-7
|
US $54.00-236.00 / mg | 99.7% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-09-06 | (3,4-Dihydroxybenzylidene)-malononitrile
118409-57-7
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- Tyrphostin 23
118409-57-7
- US $54.00-236.00 / mg
- 99.7%
- TargetMol Chemicals Inc.
-
- (3,4-Dihydroxybenzylidene)-malononitrile
118409-57-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
RARECHEM AL BX 0069
RG-50810
TYRPHOSTIN RG 50858
TYRPHOSTIN AG 18
TYRPHOSTIN A23
TYRPHOSTIN 23
ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE
AG 18
[3,4-DIHYDROXYBENZYLIDENE]MALONONITRILE
[(3,4-DIHYDROXYPHENYL)METHYLENE]-PROPENEDINITRILE
TYRPHOSTIN A23 99+%
(3,4-Dihydroxybenzylidene)-malononitrile, RG-50810
AG 18 (Tyrphostin A23)
2-(3,4-Dihydroxyphenyl)ethene-1,1-dicarbonitrile
4,5-Dihydroxybenzylidenemalononitrile
(3,4-Dihydroxyphenyl)methylene propanedinitrile
Propanedinitrile, ((3,4-dihydroxyphenyl)methylene)-
AG 18 (Tyrphostin 23)
2-(3,4-Dihydroxybenzylidene)malononitrile
AG 18 (pharmaceutical)
RG 50858
TX 825
TYRPHOSTIN 23;AG 18; AG-18; AG18
Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-
AG 18 (3,4-Dihydroxybenzylidene)malononitrile 2-(3,4-Dihydroxybenzylidene)malononitrile
Tyrphostin AG 1
α-Cyano-(3,4-dihydroxy)cinnamonitrile
AG-18(RG-50810)
α-Cyano-(3,4-dihydroxy)cinnamonitrile
AG18, >=98%
AG18,RG-50810, Tyrphostin A23, >98%
AG 18 - CAS 118409-57-7 - Calbiochem
RG-50810; TYRPHOSTIN A23; AG-18; AG18; RG 50810; RG50810
CS-931
AG 18 (Tyrphostin 23, RG-50810)
2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile
AG 18 USP/EP/BP
AG18，RG-50810， Tyrphostin A23
AG-18 (RG50858, TX-825)
Tyrphostin A23 AG18
Tyrphostin 23,inhibit,RG 50810,EGFR,Inhibitor,HER1,Tyrphostin23,AG-18,AG 18,Epidermal growth factor receptor,RG50810,Tyrphostin A 23,Tyrphostin A-23,ErbB-1,Tyrphostin-23
118409-57-7
C10H6N2O2
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Kinase/Phosphatase Biology
Receptor Tyrosine Kinase Inhibitors
Epidermal Growth Factor Receptor (EGFR)
Intracellular Signaling
Protein Kinase
All Inhibitors
Inhibitors
Tyrosine Kinase Inhibitors