VILAZODONE | 163521-12-8

VILAZODONE Properties

Melting point	203-205°C
Boiling point	745.1±60.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly)), Methanol (Slightly)
pka	15.98±0.30(Predicted)
form	Solid
color	Pale Yellow to Beige
Stability	Very Hygroscopic
InChIKey	SGEGOXDYSFKCPT-UHFFFAOYSA-N
SMILES	O1C2=CC=C(N3CCN(CCCCC4C5=C(NC=4)C=CC(C#N)=C5)CC3)C=C2C=C1C(N)=O
CAS DataBase Reference	163521-12-8
FDA UNII	S239O2OOV3
ATC code	N06AX24

SAFETY

Risk and Safety Statements

Hazardous Substances Data	163521-12-8(Hazardous Substances Data)

VILAZODONE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	V265000	Vilazodone	163521-12-8	250mg	$295	2021-12-16	Buy
ChemScene	CS-0550	Vilazodone 99.91%	163521-12-8	50mg	$396	2021-12-16	Buy
Medical Isotopes, Inc.	D34392	Vilazodone-d8HCl	163521-12-8	1mg	$675	2021-12-16	Buy
Matrix Scientific	094760	5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide 95+%	163521-12-8	250mg	$681	2021-12-16	Buy
American Custom Chemicals Corporation	API0008118	VILAZODONE 95.00%	163521-12-8	10MG	$697.2	2021-12-16	Buy

Product number	Packaging	Price	Buy
V265000	250mg	$295	Buy
CS-0550	50mg	$396	Buy
D34392	1mg	$675	Buy
094760	250mg	$681	Buy
API0008118	10MG	$697.2	Buy

VILAZODONE Chemical Properties,Uses,Production

Description

Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.

References

https://www.drugbank.ca/drugs/DB06684
https://en.wikipedia.org/wiki/Vilazodone
http://www.rxlist.com/viibryd-drug/indications-dosage.htm

Description

In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC₅₀=0.2 nM) with high affinity for 5-HT1A receptors (IC₅₀=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.

Chemical Properties

Light Yellow Solid

Originator

Merck KGaA (Germany)

Uses

Labelled analogue of Vilazodone

Uses

It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Uses

An inhibitor of ST and activator of SR-1A

Definition

ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.

brand name

Viibryd

Mechanism of action

The mechanism of action of Vilazodone antidepressant is to enhance the release of serotonin from the serotonergic pathway in the brain by inhibiting the serotonin transporter (similar to a selective serotonin reuptake inhibitor (SSRI)) while stimulating the serotonin-1a receptor through partial agonism. Its agonistic effects are similar to those of the anxiolytic drug buspirone.

Side effects

The most common side effects of Vilazodone administered orally include: diarrhoea, dizziness, headache, dry mouth, nausea, vomiting, and sleep disturbances. These symptoms are mild and may disappear within a few days or weeks. Other serious side effects that may occur include: bleeding, hyponatraemia (low levels of sodium in the blood, manifested by dizziness, light-headedness, difficulty concentrating and fainting), mania, seizures (loss of consciousness, twitching of limbs), closed-angle glaucoma (sudden eye pain or loss of vision) and allergic reactions. Seek medical attention if any of these serious adverse symptoms occur.

VILAZODONE synthesis

Synthesis of VILAZODONE from 3-(4-Chlorbutyl)-1H-indol-5-carbonitril and 5-piperazin-1-yl-1-benzofuran-2-carboxamide

VILAZODONE Preparation Products And Raw materials

Raw materials

Preparation Products

VILAZODONE Suppliers

Global( 242)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
S&Y Biochem Co.,Ltd	+8617774091612	marketing@sybiochem.com	China	128	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
S&Y Biochem Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shochem(Shanghai) Co.,Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from VILAZODONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-16	VILAZODONE 163521-12-8	US $1.00 / kg	0.1kg	99	20	S&Y Biochem Co.,Ltd
2024-11-19	Vilazodone 163521-12-8	US $54.00-197.00 / mg		99.83%	10g	TargetMol Chemicals Inc.
2024-11-19	Vilazodone 163521-12-8	US $54.00-197.00 / mg		99.83%	10g	TargetMol Chemicals Inc.

VILAZODONE
163521-12-8
US $1.00 / kg
99
S&Y Biochem Co.,Ltd

Vilazodone
163521-12-8
US $54.00-197.00 / mg
99.83%
TargetMol Chemicals Inc.

Vilazodone
163521-12-8
US $54.00-197.00 / mg
99.83%
TargetMol Chemicals Inc.

VILAZODONE Spectrum

VILAZODONE(163521-12-8)¹HNMR

163521-12-8(VILAZODONE)Related Search:

1-BENZOFURAN-5-AMINE Vilazodone Intermediate Paliperidone Linagliptin Anidulafungin

Bexarotene 8-AZAGUANINE Silodosin Vilazodone impurity 1 1H-Indole-5-carbonitrile, 3-(4-hydroxybutyl)-

3-(4-Chloro-1-hydroxybutyl)-1H-indole-5-carbonitrile ISO-PROPYLCHLOROBUTYRATE 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid Vilazodone Hydrochloride Vilazodone Impurity 24

Verazolonone related impurities Vilazodone Impurity 5 Vilazodone Impurity 30

1of4

2-BenzofurancarboxaMide,5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]- Vilazodonei Vilazodone 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide Vilazodone, >=98% Vilozodone Vilazodone [inn] VILAZODONE 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide 5-(4-(4-(5-cyano-1H-indol-3-yl) butyl) piperazin-1- yl) benzofuran-2-carboxaMide hydrochloride Vilazodone HCL EMD 515259 Vilazodone-d6 Clear Eyes Verazodone hydrochloride VIIBRYD; 5-(4-[4-(5-CYANO-1H-INDOL-3-YL)BUTYL]PIPERAZIN-1-YL)BENZOFURAN-2-CARBOXAMIDE CS-108 5-(4-(4-(5-Cyanoindol-3-yl)butyl)-1-piperazinyl)-2-benzofurancarboxamide UNII-S239O2OOV3 5‐{4‐[4‐(5‐Cyano‐1H‐indol‐3‐yl)‐butyl]‐1‐piperazinyl}‐2‐ benzofurancarboxamide VILAZODONE 163521-12-8 VILAZODONE USP/EP/BP Vilazodone (EMD 68843) VilazodoneQ: What is Vilazodone Q: What is the CAS Number of Vilazodone Q: What is the storage condition of Vilazodone Q: What are the applications of Vilazodone VILAZODONE API AK-Con All Clear 99% Vilazodonei with low price CAS NO.163521-12-8 Velazolone hydrochloride SB659746A|||EMD 68843 Velazolone 163521-12-8 123521-12-8 Other APIs Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API