BAFILOMYCIN A1 | 88899-55-2

BAFILOMYCIN A1 Properties

Melting point	>106°C (dec.)
Boiling point	582.86°C (rough estimate)
Density	1.0594 (rough estimate)
refractive index	1.5000 (estimate)
RTECS	RN9781000
Flash point	87℃
storage temp.	-20°C
solubility	Soluble in DMSO (up to 5 mg/ml, with warming).
pka	12.66±0.70(Predicted)
form	Powder or Solid
color	White to off-white
Water Solubility	Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
BRN	4730700
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335-H227

Precautionary statements

P210e-P280a-P370+P378a-P403+P235-P501a-P261-P304+P340-P305+P351+P338-P405

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

3172

WGK Germany

3

F

10

HazardClass

6.1(b)

PackingGroup

III

HS Code

29419090

NFPA 704

	0
2		0

BAFILOMYCIN A1 price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B1793	Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC)	88899-55-2	2μg	$86.8	2024-03-01	Buy
Sigma-Aldrich	SML1661	Bafilomycin A1 Ready Made Solution 0.16?mMinDMSO,fromStreptomycesgriseus	88899-55-2	0.1ml	$220	2024-03-01	Buy
Sigma-Aldrich	B1793	Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC)	88899-55-2	10μg	$210	2024-03-01	Buy
Sigma-Aldrich	5.08409	InSolution Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem A 100 μM (15 μg/241 μL) sterile-filtered solution of Bafilomycin A1,	88899-55-2	15μG	$280	2024-03-01	Buy
Sigma-Aldrich	196000	Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.	88899-55-2	10μG	$201	2024-03-01	Buy

Product number	Packaging	Price	Buy
B1793	2μg	$86.8	Buy
SML1661	0.1ml	$220	Buy
B1793	10μg	$210	Buy
5.08409	15μG	$280	Buy
196000	10μG	$201	Buy

BAFILOMYCIN A1 Chemical Properties,Uses,Production

Description

Bafilomycin A₁ is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H⁺-ATPases (V-ATPases; K_i = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na⁺/K⁺-, Ca²⁺-, and H⁺-ATPases. Bafilomycin A₁ (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A₁ (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

Chemical Properties

white to off-white powder

Uses

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Uses

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Uses

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Definition

ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

General Description

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).

Biological Activity

Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.

storage

-20°C

References

1) Werner?et al.? (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot.,?37?110 2) Drose and Altendorf? (1997)?Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase;?J. Exp. Biol.,?200?1 3) Yamamoto?et al. (1998)?Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells;?Cell Struct. Func.,?23?33

BAFILOMYCIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

BAFILOMYCIN A1 Suppliers

Global( 213)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	8946	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58

View Lastest Price from BAFILOMYCIN A1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-18	Bafilomycin A1 88899-55-2	US $699.00-287.00 / mg		99.14%	10g	TargetMol Chemicals Inc.
2021-07-17	BAFILOMYCIN A1 USP/EP/BP 88899-55-2	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2019-07-06	BAFILOMYCIN A1 88899-55-2	US $1.00 / kg	1kg	95%-99%	100kg	Career Henan Chemical Co

Bafilomycin A1
88899-55-2
US $699.00-287.00 / mg
99.14%
TargetMol Chemicals Inc.

BAFILOMYCIN A1 USP/EP/BP
88899-55-2
US $1.10 / g
99.9%
Dideu Industries Group Limited

BAFILOMYCIN A1
88899-55-2
US $1.00 / kg
95%-99%
Career Henan Chemical Co

BAFILOMYCIN A1 Spectrum

BAFILOMYCIN A1(88899-55-2)¹HNMR

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Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus Bafilomycin A1(Baf-A1) BAFILOMYCIN A1 BAFILOMYCIN A1, STREPTOMYCES GRISEUS BAFILOMYCIN A1, 98+% BAFILOMYCIN A1 95% (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5 BafilomycinA1fromStreptomycesgriseus 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Bafilomycin A1,95% (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o Bafilomycin A1 from Streptomycesgriseus, 10 ug Bafilomycin A1, 95%, from Streptomyces griseus CS-1163 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)- BafilomycinBafilomycin A1Bafilomycin A1, from Streptomyces griseus BAFILOMYCIN A1 USP/EP/BP (3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one afilomycin A1 (3Z,5E,11E,13E)-16-[4-(2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl)-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one Bafilomycin A1, (V)-ATPase inhibitor 88899-55-2 C35H58O9 Antibiotics A-F Antibiotics A to Z Antibiotics BioChemical antibiotic A - KAntibiotics Antibacterial Antibiotics A to Antibiotics A-FAntibiotics Antibiotics by Application AntifungalAntibiotics Antineoplastic and Immunosuppressive AntibioticsAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics MacrolidesMore...Close... Mechanism of Action Spectrum of Activity Peptide Synthesis/Antibiotics