Cytidine 5'-Diphosphocholine
- CAS No.
- 987-78-0
- Chemical Name:
- Cytidine 5'-Diphosphocholine
- Synonyms
- CITICOLINE;CDP-CHOLINE;citicholine;CYTIDINE DIPHOSPHATE CHOLINE;Reagin;somazina;Audes;cereb;Rexort;CDPC-H
- CBNumber:
- CB4343598
- Molecular Formula:
- C14H26N4O11P2
- Molecular Weight:
- 488.33
- MDL Number:
- MFCD00868097
- MOL File:
- 987-78-0.mol
| Melting point | >185°C (dec.) |
|---|---|
| alpha | D25 +19.0° (c = 0.86 in H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Water (Sparingly) |
| pka | 4.4(at 25℃) |
| form | Solid |
| color | White |
| Stability | Moisture Sensitive |
| InChIKey | RZZPDXZPRHQOCG-APGYLPRWNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O |&1:1,2,3,21,r| |
| LogP | -7.070 (est) |
| CAS DataBase Reference | 987-78-0(CAS DataBase Reference) |
| FDA UNII | 536BQ2JVC7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Toxicity | LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau) |
Cytidine 5'-Diphosphocholine price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C998313 | Cytidine5''-Diphosphocholine | 987-78-0 | 250mg | $45 | 2021-12-16 | Buy |
| TRC | C998313 | Cytidine5''-Diphosphocholine | 987-78-0 | 2.5g | $70 | 2021-12-16 | Buy |
| AK Scientific | K771 | Citicoline | 987-78-0 | 25g | $81 | 2021-12-16 | Buy |
| ApexBio Technology | C6983 | Citicoline | 987-78-0 | 500mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0009633 | Citicoline 99.51% | 987-78-0 | 500mg | $90 | 2021-12-16 | Buy |
Cytidine 5'-Diphosphocholine Chemical Properties,Uses,Production
Description
Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced.
Originator
Nicholin,Cyanamid,Italy,1971
Uses
Cytidine 5'-Diphosphocholine is used as antidepressant, 5HT uptake inhibitor.
Definition
ChEBI: CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).
Manufacturing Process
A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a
composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'-
monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of
acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml
of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96
mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at
30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated
at a concentration of 3.8 mg/ml in the culture liquor.
The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate
choline, obtained by removing solid matters from the culturing liquor, was
adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed
through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic
acid type). After washing the resin with water, a formic acid solution was
passed through the column with gradual increase in the concentration of
formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was
collected by elution according to the so-called gradient elution method and
absorbed onto carbon powders. Then, elution was effected with acetone, and
the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline (Cytidine 5'-Diphosphocholine) powders were obtained.
Therapeutic Function
Cerebral circulation stimulant
benefits
Citicoline (CDP-choline; Cytidine 5'-Diphosphocholine), a naturally occurring endogenous compound, is an essential intermediate in the biosynthesis of cell membrane phospholipids. Produced endogenously, citicoline serves as a choline donor in the metabolic pathways for the biosynthesis of acetylcholine and neuronal membrane phospholipids, mainly phosphatidylcholine. When a citicoline supplement is taken by mouth or intravenously, its two main components, cytidine and choline, are fully absorbed into the bloodstream. Once absorbed, citicoline is widely distributed throughout the body and can cross the blood-brain barrier and reach the central nervous system (CNS), where it is incorporated into phospholipids. Citicoline activates the biosynthesis of structural phospholipids that form neuronal membranes, increases brain metabolism, and influences levels of multiple neurotransmitters. Citicoline has increased acetylcholine, norepinephrine and dopamine levels in the central nervous system. Citicoline has been proposed to protect nerve cells after cerebral ischemia. In animal studies, it has been found to improve learning and memory. Citicoline may be used as a treatment for cerebral vascular disease after head trauma and cognitive impairment arising from multiple causes. Citicoline helps recovery from post-traumatic coma and neurological deficits in those who have had an ischemic cerebral vascular disease such as stroke. Additional uses of citicoline include treatment of age-related cognitive decline and degenerative neurological diseases such as Alzheimer's disease.
Cytidine 5'-Diphosphocholine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xinxiang Aurora Biotechnology Co.,Ltd. | +86-0086-0373-3088722 +8618637352520 | info@aurora-biotech.com | China | 93 | 58 |
| Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 | linda@xrdchem.cn | China | 196 | 58 |
| Hangzhou Weitai Biological Pharmaceutical Co.,Ltd. | +8613282012786 | sales@weitai-pharmaceutical.com | China | 61 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2633 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
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- Nov 5，2024
- Side effects of Citicoline
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- May 6，2022
- Cytidine 5′-Diphosphocholine (CDP-Choline) in Stroke and Other CNS Disorders
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View Lastest Price from Cytidine 5'-Diphosphocholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Citicoline
987-78-0
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min HPLC | 1000 KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-22 | Citicoline / CDP choline
987-78-0
|
US $0.00 / Kg/Bag | 2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-11-22 | Citicoline
987-78-0
|
US $0.00-0.00 / Kg | 1Kg | 98% | 20Ton | Xinxiang Aurora Biotechnology Co.,Ltd. |
-
- Citicoline
987-78-0
- US $0.00-0.00 / Kg/Drum
- 99%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Citicoline / CDP choline
987-78-0
- US $0.00 / Kg/Bag
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- Citicoline
987-78-0
- US $0.00-0.00 / Kg
- 98%
- Xinxiang Aurora Biotechnology Co.,Ltd.