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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

CAS No.
1892-57-5
Chemical Name:
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms
EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;1-(3-Dimethylaminopropyl)-3-;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;WSC【Dotite】
CBNumber:
CB4403030
Molecular Formula:
C8H17N3
Molecular Weight:
155.24
MDL Number:
MFCD00044916
MOL File:
1892-57-5.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:57

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Properties

Boiling point 66-68°C/1mm
Density 0.877 g/mL at 20 °C (lit.)
refractive index n20/D 1.461
Flash point 66-68°C/1mm
storage temp. -20°C
solubility Chloroform
pka 9.52±0.28(Predicted)
form Liquid
Specific Gravity 0.885
color Colorless to slightly yellow
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 507429
InChIKey LMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference 1892-57-5(CAS DataBase Reference)
FDA UNII RJ5OZG6I4A
NIST Chemistry Reference 1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H311-H315-H317-H373-H410
Precautionary statements  P260-P273-P280-P301+P312-P302+P352+P312-P314
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 2735 8/PG 3
WGK Germany  3
1-3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29252900
NFPA 704
1
3 1

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 39391 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T) 1892-57-5 10ml $185 2024-03-01 Buy
Sigma-Aldrich 39391 N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T) 1892-57-5 50ml $798 2024-03-01 Buy
TCI Chemical D4029 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T) 1892-57-5 5g $80 2024-03-01 Buy
TCI Chemical D4029 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T) 1892-57-5 25g $240 2024-03-01 Buy
Alfa Aesar B25057 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% 1892-57-5 5g $106 2024-03-01 Buy
Product number Packaging Price Buy
39391 10ml $185 Buy
39391 50ml $798 Buy
D4029 5g $80 Buy
D4029 25g $240 Buy
B25057 5g $106 Buy

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Uses,Production

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

Chemical Properties

Clear light yellow liquid

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

General Description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Synthesis

The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

References

[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.

25952-53-8
1892-57-5
Synthesis of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials

Global( 341)Suppliers
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Shanghai Z&T Chemical Co., Ltd
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View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide pictures 2024-12-13 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide pictures 2024-11-21 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
US $10.00 / KG 100KG 99% 100 mt Hebei Weibang Biotechnology Co., Ltd
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide pictures 2024-10-25 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
US $30.00-9.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
N'-(ethylcarbonimidoyl)-N,N-dimethylpropane-1,3-diamine EDC polymer-bound, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide polymer-bound, N-(3-Dimethylaminopropyl)-Nμ-ethylcarbodiimide polymer-bound EDC, WSC, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide 1-ehyl-3-(dimethylaminopropyl)carbodiimide 3-[(Ethylcarbonimidoyl)amino]-N,N-dimethyl-1-propanamine WSC【Dotite】 3-(ethyliminomethyleneamino)propyl-dimethyl-amine 3-(ethyliminomethylideneamino)-N,N-dimethyl-propan-1-amine 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine N-(3-Dimethylaminopr N-(3-DiMethylaMinopropyl)-N'-ethylcarb N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide(EDCI) N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide >=97.0% (T) 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide EDC EDAC 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide(EDC) 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE WATER-SOLUBLE CARBODIIMIDE N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE [3-(Dimethylamino)propyl]ethylcarbodiimide ethyldimethylaminopropylcarbodiimide n’-(ethylcarbonimidoyl)-n,n-dimethyl-3-propanediamine N3-Ethyliminomethylene-N1,N1-dimethylpropane-1,3-diamine 1-(3-dimethylaminopropyl)-N?ethylcarbodiimide Rivaroxaban Impurity 139 N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diamin 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 98% 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 97%, for synthesis 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide> 1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl- N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97% EDAC EDCI N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine ({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine 1-(3-Dimethylaminopropyl)-3- 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE WSCD WSCI N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE Avanafil Impurity 72 1-ETHYL-(3- DIMETHYLAMINOPROPYL)CARBODIIMIDE (EDC Free Base) 1-(3-Dimethylaminopropyl)-3- ethylcarb n'-(ethylkohlenstoffimidoyl)-n,n-dimethylpropan-1,3-diamin N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide 1892-57-5 25952-83-0 CH3CH2NCNCH23NCH32 C8H17N3 BioChemical Carbodiimides Reagents for Protein Sequencing Protein Sequencing Protein Analysis Proteomics and Protein Expression Synthetic Reagents Coupling straight chain compounds