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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE structure

CAS No.: 56741-95-8

Chemical Name:: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Synonyms: U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;Bropirimine, 10 mM in DMSO;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol

CBNumber:: CB5225165

Molecular Formula:: C10H8BrN3O

Molecular Weight:: 266.09

MDL Number:: MFCD00813905

MOL File:: 56741-95-8.mol

Last updated:2025-01-27 09:38:02

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Properties

Melting point	285-287° (Stevens); mp 246-248° (Brown, Stevens)
Boiling point	389.7±52.0 °C(Predicted)
Density	1.6292 (rough estimate)
refractive index	1.6520 (estimate)
storage temp.	room temp
solubility	DMSO: ≥5mg/mL (warm DMSO)
form	powder
pka	3.18; 8.53(at 25℃)
color	white to beige
Water Solubility	7.8mg/L(37 ºC)
FDA UNII	J57CTF25XJ
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P281
Hazard Codes	Xn
Risk Statements	63-62
WGK Germany	3
RTECS	UW7351300

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0218	Bropirimine ≥98% (HPLC)	56741-95-8	10mg	$106	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	10mg	$57	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	25mg	$116	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	5mg	$32	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	50mg	$199	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0218	10mg	$106	Buy
29440	10mg	$57	Buy
29440	25mg	$116	Buy
29440	5mg	$32	Buy
29440	50mg	$199	Buy

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Uses,Production

Description

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Uses

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Uses

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Definition

ChEBI: Bropirimine is a member of pyrimidines.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

storage

Desiccate at RT

Toxics Screening Level

The initial threshold screening level (ITSL) for bropirimine is 15 μg/m3 based on an annual averaging time.

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Suppliers

Global( 95)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30231	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

Supplier	Advantage
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Dideu Industries Group Limited	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-17	Bropirimine 56741-95-8	US $44.00-116.00 / mg		99.01%	10g	TargetMol Chemicals Inc.
2021-07-02	2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP 56741-95-8	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2020-05-03	Bropirimine 56741-95-8	US $0.00-0.00 / Kg	1KG	99.0%	800 ton	Shaanxi Dideu Medichem Co. Ltd

Bropirimine
56741-95-8
US $44.00-116.00 / mg
99.01%
TargetMol Chemicals Inc.

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
56741-95-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

Bropirimine
56741-95-8
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

56741-95-8(2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE)Related Search:

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2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-5-bromo-6-phenylpyrimidin-4-ol 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one PNU-54461 U-54461 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone 2-AMino-5-broMo-6-phenyl-4-pyriMidinol 2-AMino-5-broMo-6-phenyl-4-pyriMidinone 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone 5-BroMo-6-phenylisocytosine NSC 149027 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl- 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine U 54461S 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone bropirimine 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit Bromopilimine Bropirimine, 10 mM in DMSO 56741-95-8 C10H8BrN3O Heterocycle-Pyrimidine series Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals