2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘
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2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 속성
- 녹는점
- 285-287° (Stevens); mp 246-248° (Brown, Stevens)
- 끓는 점
- 389.7±52.0 °C(Predicted)
- 밀도
- 1.6292 (rough estimate)
- 굴절률
- 1.6520 (estimate)
- 저장 조건
- room temp
- 용해도
- DMSO: ≥5mg/mL(따뜻한 DMSO)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 3.18; 8.53(at 25℃)
- 색상
- 흰색에서 베이지색
- 수용성
- 7.8mg/L(37℃)
2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 C화학적 특성, 용도, 생산
개요
Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).용도
Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.Biochem/physiol Actions
Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 준비 용품 및 원자재
원자재
준비 용품
2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 공급 업체
글로벌( 86)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 |
karmelhk@126.com | CHINA | 2886 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 관련 검색:
Bromisoval
Neostigmine bromide
Mestinon
2-Amino-4-hydroxy-6-phenylpyrimidine
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
2-Amino-5-bromopyrimidine
5-BROMO-6-METHYLPYRIMIDIN-4-OL
5-Bromo-4-phenylpyrimidine
2-Amino-4-methyl-5-bromopyrimidine
5-bromo-1H-pyrimidin-4-one
2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE
N2-ACETYLAMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE
2-amino-5-bromo-4-pyrimidinol
Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)