ChemicalBook >제품 카탈로그 >2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 구조식 이미지

카스 번호:: 56741-95-8

한글명:: 2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘

동의어(한글):: 2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘

상품명:: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

동의어(영문):: U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone

CBNumber:: CB5225165

분자식:: C10H8BrN3O

포뮬러 무게:: 266.09

MOL 파일:: 56741-95-8.mol

속성

안전

용도

공급 업체 86

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 속성

녹는점: 285-287° (Stevens); mp 246-248° (Brown, Stevens)

끓는 점: 389.7±52.0 °C(Predicted)

밀도: 1.6292 (rough estimate)

굴절률: 1.6520 (estimate)

저장 조건: room temp

용해도: DMSO: ≥5mg/mL(따뜻한 DMSO)

물리적 상태: 가루

산도 계수 (pKa): 3.18; 8.53(at 25℃)

색상: 흰색에서 베이지색

수용성: 7.8mg/L(37℃)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	63-62
WGK 독일	3
RTECS 번호	UW7351300

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H361	태아 또는 생식능력에 손상을 일으킬 것으로 의심됨	생식독성 물질	구분 2	경고		P201, P202, P281, P308+P313, P405,P501

예방조치문구:

P281

요구되는 개인 보호구를 착용하시오

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 C화학적 특성, 용도, 생산

개요

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

용도

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 준비 용품 및 원자재

원자재

준비 용품

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 공급 업체

글로벌( 86)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30238	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22787	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

2-아미노-5-브로모-4-하이드록시-6-페닐피리미딘 관련 검색:

Bromisoval Neostigmine bromide Mestinon 2-Amino-4-hydroxy-6-phenylpyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-5-bromopyrimidine 5-BROMO-6-METHYLPYRIMIDIN-4-OL 5-Bromo-4-phenylpyrimidine 2-Amino-4-methyl-5-bromopyrimidine 5-bromo-1H-pyrimidin-4-one 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE N2-ACETYLAMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 2-amino-5-bromo-4-pyrimidinol Pyrimidine, 5-bromo-4-methyl- (7CI,8CI,9CI)