CAY10607
- CAS No.
- 1012788-65-6
- Chemical Name:
- CAY10607
- Synonyms
- CAY10607;CAY10607 Exclusive;Benzisoxazole Hsp90 Inhibitor;1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-
- CBNumber:
- CB52590441
- Molecular Formula:
- C19H20ClN3O4
- Molecular Weight:
- 389.83
- MDL Number:
- MFCD18382085
- MOL File:
- 1012788-65-6.mol
CAY10607 price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10012694 | Benzisoxazole Hsp90 Inhibitor ≥98% | 1012788-65-6 | 1mg | $120 | 2024-03-01 | Buy |
Cayman Chemical | 10012694 | Benzisoxazole Hsp90 Inhibitor ≥98% | 1012788-65-6 | 5mg | $537 | 2024-03-01 | Buy |
Cayman Chemical | 10012694 | Benzisoxazole Hsp90 Inhibitor ≥98% | 1012788-65-6 | 10mg | $952 | 2024-03-01 | Buy |
TRC | B201968 | BenzisoxazoleHsp90Inhibitor | 1012788-65-6 | 2.5mg | $340 | 2021-12-16 | Buy |
AK Scientific | 1409AH | 4-Chloro-6-(5-((2-(4-morpholinyl)ethyl)amino)-1,2-benzisoxazol-3-yl)-1,3-benzenediol | 1012788-65-6 | 5mg | $695 | 2021-12-16 | Buy |
CAY10607 Chemical Properties,Uses,Production
Description
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 μM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 μM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 μM for both.
Uses
Benzisoxazole Hsp90 Inhibitor is an inhibitor that binds to the N-terminal domain of Hsp90.
Definition
ChEBI: 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol is a member of the class of 1,2-benzoxazoles carrying 2,4-dihydroxy-4-chlorophenyl and (2-morpholin-4-ylethyl)amino substituents at positions 3 and 5 respectively. It has a role as a Hsp90 inhibitor. It is a member of 1,2-benzoxazoles, a member of morpholines, a member of resorcinols, a member of monochlorobenzenes, a tertiary amino compound, a secondary amino compound and an aromatic amine.
CAY10607 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10607 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7980 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Supplier | Advantage |
---|---|
Alfa Chemistry | 58 |
Aladdin Scientific | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 58 |
Energy Chemical | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |