CAY10607

CAY10607 구조식 이미지
카스 번호:
1012788-65-6
상품명:
CAY10607
동의어(영문):
CAY10607;CAY10607 Exclusive;Benzisoxazole Hsp90 Inhibitor;1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-
CBNumber:
CB52590441
분자식:
C19H20ClN3O4
포뮬러 무게:
389.83
MOL 파일:
1012788-65-6.mol

CAY10607 속성

저장 조건
Store at -20°C
용해도
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
물리적 상태
결정성 고체

안전

CAY10607 C화학적 특성, 용도, 생산

개요

Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 μM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 μM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 μM for both.

CAY10607 준비 용품 및 원자재

원자재

준비 용품


CAY10607 공급 업체

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