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11-Piperazinyldibenzo[b,e][1,4]diazepine

11-Piperazinyldibenzo[b,e][1,4]diazepine structure

CAS No.: 56296-18-5

Chemical Name:: 11-Piperazinyldibenzo[b,e][1,4]diazepine

Synonyms: DREADD agonist 1;DREADD Agonist 21;DREADD agonist 21, 10 mM in DMSO;DREADD Agonist 21, DREADD agonist;11-Piperazinyldibenzo[b,e][1,4]diazepine;11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-;Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors

CBNumber:: CB52650796

Molecular Formula:: C17H18N4

Molecular Weight:: 278.35

MDL Number:: MFCD25121806

MOL File:: 56296-18-5.mol

Last updated:2025-04-17 18:22:24

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11-Piperazinyldibenzo[b,e][1,4]diazepine Properties

Boiling point	470.1±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM) Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM)
form	A crystalline solid
pka	8.56±0.10(Predicted)
color	Yellow
Water Solubility	H2O: 2mg/mL, clear
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

11-Piperazinyldibenzo[b,e][1,4]diazepine price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18907	DREADD Agonist 21 ≥98%	56296-18-5	1mg	$48	2024-03-01	Buy
Cayman Chemical	18907	DREADD Agonist 21 ≥98%	56296-18-5	5mg	$117	2024-03-01	Buy
Cayman Chemical	18907	DREADD Agonist 21 ≥98%	56296-18-5	10mg	$210	2024-03-01	Buy
Tocris	5548	DREADDagonist21 ≥98%(HPLC)	56296-18-5	10	$203	2021-12-16	Buy
Tocris	5548	DREADDagonist21 ≥98%(HPLC)	56296-18-5	50	$852	2021-12-16	Buy

Product number	Packaging	Price	Buy
18907	1mg	$48	Buy
18907	5mg	$117	Buy
18907	10mg	$210	Buy
5548	10	$203	Buy
5548	50	$852	Buy

11-Piperazinyldibenzo[b,e][1,4]diazepine Chemical Properties,Uses,Production

Description

DREADD agonist 21 activates hM3Dq (EC₅₀ = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M₃ receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT_2A, 5-HT_2C, α_1A-adrenergic, and histamine H₁ receptors (K_is = 66, 170, 280, and 6 nM, respectively).

Uses

DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.

in vivo

DREADD agonist 21 (0.3, 1.0, and 3.0 mg/kg; i.p.) activates neuronal hM3Dq in mice^[2].
? DREADD agonist 21 has excellent bioavailability, pharmacokinetic properties, and brain penetrability. DREADD agonist 21 (0.1, 1, and 10 mg/kg; i.p.) displays 95.1% plasma protein binding and 95% brain protein bounding in mice^[2].

IC 50

mAChR3

storage

Room temperature

11-Piperazinyldibenzo[b,e][1,4]diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

11-Piperazinyldibenzo[b,e][1,4]diazepine Suppliers

Global( 66)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30230	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38636	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai EFE Biological Technology Co., Ltd.	58

View Lastest Price from 11-Piperazinyldibenzo[b,e][1,4]diazepine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	DREADD agonist 21 56296-18-5	US $53.00-143.00 / mg		99.88%	10g	TargetMol Chemicals Inc.
	2024-11-19	DREADD agonist 21 56296-18-5	US $53.00-143.00 / mg		99.88%	10g	TargetMol Chemicals Inc.

DREADD agonist 21
56296-18-5
US $53.00-143.00 / mg
99.88%
TargetMol Chemicals Inc.

DREADD agonist 21
56296-18-5
US $53.00-143.00 / mg
99.88%
TargetMol Chemicals Inc.

11-Piperazinyldibenzo[b,e][1,4]diazepine DREADD Agonist 21 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine DREADD agonist 1 5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)- Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine DREADD Agonist 21, DREADD agonist DREADD agonist 21, 10 mM in DMSO 56296-18-5