ChemicalBook >> CAS DataBase List >>11-Piperazinyldibenzo[b,e][1,4]diazepine
11-Piperazinyldibenzo[b,e][1,4]diazepine
![11-Piperazinyldibenzo[b,e][1,4]diazepine Structure](CAS/20150408/GIF/56296-18-5.gif)
- CAS No.
- 56296-18-5
- Chemical Name:
- 11-Piperazinyldibenzo[b,e][1,4]diazepine
- Synonyms
- DREADD agonist 1;DREADD Agonist 21;11-Piperazinyldibenzo[b,e][1,4]diazepine;11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-;Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors
- CBNumber:
- CB52650796
- Molecular Formula:
- C17H18N4
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD25121806
- MOL File:
- 56296-18-5.mol
Last updated:2023-06-30 15:45:59
| Boiling point | 470.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM) Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM) |
| form | A crystalline solid |
| pka | 8.56±0.10(Predicted) |
| color | Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
11-Piperazinyldibenzo[b,e][1,4]diazepine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18907 | DREADD Agonist 21 ≥98% | 56296-18-5 | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 18907 | DREADD Agonist 21 ≥98% | 56296-18-5 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 18907 | DREADD Agonist 21 ≥98% | 56296-18-5 | 10mg | $210 | 2024-03-01 | Buy |
| Tocris | 5548 | DREADDagonist21 ≥98%(HPLC) | 56296-18-5 | 10 | $203 | 2021-12-16 | Buy |
| Tocris | 5548 | DREADDagonist21 ≥98%(HPLC) | 56296-18-5 | 50 | $852 | 2021-12-16 | Buy |
11-Piperazinyldibenzo[b,e][1,4]diazepine Chemical Properties,Uses,Production
Description
DREADD agonist 21 activates hM3Dq (EC50 = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT2A, 5-HT2C, α1A-adrenergic, and histamine H1 receptors (Kis = 66, 170, 280, and 6 nM, respectively).
Uses
DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.
storage
Room temperature
11-Piperazinyldibenzo[b,e][1,4]diazepine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
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| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
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| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2986 | 58 |
11-Piperazinyldibenzo[b,e][1,4]diazepine
DREADD Agonist 21
11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
DREADD agonist 1
5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-
Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors
11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
56296-18-5