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ChemicalBook >> CAS DataBase List >>(25S)-Δ7-Dafachronic Acid

(25S)-Δ7-Dafachronic Acid

(25S)-Δ7-Dafachronic Acid Structure
(25S)-Δ7-Dafachronic Acid structure
CAS No.
949004-12-0
Chemical Name:
(25S)-Δ7-Dafachronic Acid
Synonyms
(25S)-Δ7-Dafachronic Acid;(25S)-Delta(7)-dafachronic acid;(5α,25S)-3-oxo-cholest-7-en-26-oicacid;Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-;(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid;(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
CBNumber:
CB53152417
Molecular Formula:
C27H42O3
Molecular Weight:
414.62
MDL Number:
MOL File:
949004-12-0.mol
Last updated:2023-06-30 15:45:59
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(25S)-Δ7-Dafachronic Acid Properties

storage temp. Store at -20°C
solubility DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
form A crystalline solid
color White to off-white

(25S)-Δ7-Dafachronic Acid price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14101 (25S)-Δ7-Dafachronic Acid ≥95% 949004-12-0 100μg $289 2024-03-01 Buy
Cayman Chemical 14101 (25S)-Δ7-Dafachronic Acid 949004-12-0 500μg $1156 2024-03-01 Buy
Cayman Chemical 14101 (25S)-Δ7-Dafachronic Acid 949004-12-0 1mg $2168 2024-03-01 Buy
AK Scientific 0201DB (25S)-delta(7)-Dafachronicacid 949004-12-0 1mg $2604 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0014-C100 (25S)-Δ7-Dafachronicacid ≥95%(HPLC) 949004-12-0 100μg $270 2021-12-16 Buy
Product number Packaging Price Buy
14101 100μg $289 Buy
14101 500μg $1156 Buy
14101 1mg $2168 Buy
0201DB 1mg $2604 Buy
AG-CN2-0014-C100 100μg $270 Buy

(25S)-Δ7-Dafachronic Acid Chemical Properties,Uses,Production

Description

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.

Definition

ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group).

storage

+4°C

(25S)-Δ7-Dafachronic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

(25S)-Δ7-Dafachronic Acid Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9708 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
amyjetsci 027-59626688 18771149750 sales@amyjet.com China 3004 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
United States Biological -- sales@advtechind.com United States 6106 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
amyjetsci 58
TargetMol Chemicals Inc. 58
United States Biological 58
(25S)-Δ7-Dafachronic Acid (25S)-Delta(7)-dafachronic acid (2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)- (25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid (5α,25S)-3-oxo-cholest-7-en-26-oicacid 949004-12-0