Neutrophil Elastase Inhibitor
- CAS No.
- 1448314-31-5
- Chemical Name:
- Neutrophil Elastase Inhibitor
- Synonyms
- Neutrophil Elastase Inhibitor;Neutrophil elastase inhibitor 1;1-(3-methylbenzoyl)indazole-3-carbonitrile;Neutrophil Elastase Inhibitor Exclusive;1H-Indazole-3-carbonitrile, 1-(3-methylbenzoyl)-
- CBNumber:
- CB53152699
- Molecular Formula:
- C16H11N3O
- Molecular Weight:
- 261.28
- MDL Number:
- MOL File:
- 1448314-31-5.mol
Neutrophil Elastase Inhibitor price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14922 | Neutrophil Elastase Inhibitor ≥95% | 1448314-31-5 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14922 | Neutrophil Elastase Inhibitor ≥95% | 1448314-31-5 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 14922 | Neutrophil Elastase Inhibitor ≥95% | 1448314-31-5 | 25mg | $270 | 2024-03-01 | Buy |
| Cayman Chemical | 14922 | Neutrophil Elastase Inhibitor ≥95% | 1448314-31-5 | 50mg | $477 | 2024-03-01 | Buy |
| ApexBio Technology | C3252 | NeutrophilElastaseInhibitor | 1448314-31-5 | 50mg | $543 | 2021-12-16 | Buy |
Neutrophil Elastase Inhibitor Chemical Properties,Uses,Production
Biological Activity
neutrophil elastase inhibitor is a neutrophil elastase inhibitor.human neutrophil elastase (hne) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. hne is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix.
in vitro
previous study found that neutrophil elastase inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. in addition, neutrophil elastase inhibitor appeared to be a specific hne inhibitors in a competitive manner. moreoer, the hydrolysis of the acyl-enzyme complex for neutrophil elastase inhibitor was found to be much slower than spontaneous hydrolysis of neutrophil elastase inhibitor, and hne was observed to be still inhibited to 80% of control level at 7 h after treatment [1].
IC 50
7 nm
References
[1] l. crocetti, i. a. schepetkin, a. cilibrizzi, et al. optimization of n-benzoylindazole derivatives as inhibitors of human neutrophil elastase. journal of medicinal chemistry 56(15), 6259-6272 (2013).
Neutrophil Elastase Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
Neutrophil Elastase Inhibitor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4997 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Aikon International Limited | 18626450290 | yftan@aikonchem.com | China | 10718 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 955 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5595 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |