Lobeglitazone Sulfate
- CAS No.
- 763108-62-9
- Chemical Name:
- Lobeglitazone Sulfate
- Synonyms
- CKD501;CKD-501;CKD 501;Chong Kun Dang;Lobeglitazone Sulfate;Lobeglitazone Sulfate. trade name Duvie;Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang
- CBNumber:
- CB53159926
- Molecular Formula:
- C24H26N4O9S2
- Molecular Weight:
- 578.61
- MDL Number:
- MFCD28502044
- MOL File:
- 763108-62-9.mol
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | 95C712E83P |
Lobeglitazone Sulfate Chemical Properties,Uses,Production
Description
Lobeglitazone sulfate, an oral peroxisome proliferator-activated receptor (PPARa/c) dual agonist with IC50 = 20 and 18 nM respectively, was developed by Chong Kun Dang Pharmaceutical in Korea for the treatment of diabetes. This drug is differentiated from two other PPAR agonists available—pioglitazone and rosiglitazone —which lack PPARa activity. The most likely processscale preparation of lobeglitazone sulfate follows the route described in a process communication from Chong Kun Dang Pharmaceutical.
Synthesis
Commercially available 4,6-dichloropyrimidine (152) was treated with a stoichiometric equivalent of p-methoxyphenol (153) in the presence of KF in warm DMF . Upon completion of this reaction, 2-methylaminoethanol was added to the mixture to provide pyrimidine 154 in high yield. Next, alcohol 154 underwent a substitution reaction with p-fluorobenzaldehyde (155) under basic conditions to provide alkoxy benzaldehyde 156 which was converted to the benzylidene thiazolidindione 158 upon subjection to Knoevenagel conditions with 2,4-thiazolidinedione (157) in 90% yield. Finally, reduction of olefin 158 was facilitated by treatment with the Hantzsch ester (159) in the presence of silica gel followed by treatment with methanolic sulfuric acid (96%) at low temperature to ultimately furnish lobeglitazone sulfate in 90% yield.
Lobeglitazone Sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Lobeglitazone Sulfate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4287 | 55 | |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
| Heyuan broad spectrum Biotechnology Co., Ltd | 0762-3393039 18023108599 | 2853058244@qq.com | China | 984 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Nanjing Pope Bio-tech R&D Co., Ltd | 025-87138562 18951783565 | sales@popebiotech.com | China | 1101 | 58 |
| Allikang Pharmaceutical Co., LTD | 0573-87390950 13806705416 | wzj@alicornpharma.com | China | 71 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2540 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4578 | 58 |