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Lerisetron

Lerisetron Structure
Lerisetron structure
CAS No.
143257-98-1
Chemical Name:
Lerisetron
Synonyms
CID 65997;F-0930-RS;Lerisetron;Lerisetron, 10 mM in DMSO;1-benzyl-2-piperazin-1-ylbenzimidazole;1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE;1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole;1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole;1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)-;1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride
CBNumber:
CB61179015
Molecular Formula:
C18H20N4
Molecular Weight:
292.38
MDL Number:
MFCD00865529
MOL File:
143257-98-1.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:15
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Lerisetron Properties

storage temp. Store at -20°C
solubility DMSO: 58 mg/mL (198.37 mM);Ethanol: 58 mg/mL (198.37 mM)
form Solid
color White to off-white
Water Solubility Water: Insoluble
FDA UNII Q36R82SXRG
NCI Drug Dictionary lerisetron

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H302-H335-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Lerisetron price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0009131 LERISETRON 95.00% 143257-98-1 5MG $500.83 2021-12-16 Buy
Matrix Scientific 137090 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride 95% 143257-98-1 1g $611 2021-12-16 Buy
AK Scientific 3845CA Lerisetron 143257-98-1 100mg $623 2021-12-16 Buy
Matrix Scientific 137090 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride 95% 143257-98-1 2.500g $1334 2021-12-16 Buy
AK Scientific 3845CA Lerisetron 143257-98-1 5g $1724 2021-12-16 Buy
Product number Packaging Price Buy
API0009131 5MG $500.83 Buy
137090 1g $611 Buy
3845CA 100mg $623 Buy
137090 2.500g $1334 Buy
3845CA 5g $1724 Buy

Lerisetron Chemical Properties,Uses,Production

Uses

Lerisetron is a potent 5-HT3 antagonists and possess high-affinity binding for the 5-HT3 receptors with pKi value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats[1].

in vivo

Lerisetron (50-200 μg/kg; IV; single) exhibits CL of 0.004-0.005 L/min, Vds of 0.88-0.96 L, MRT0-LAST of 224-337.1 min and AUC∞ of 57.7-66.1 μg·min/L in rats[2].
Lerisetron (2-10 μg/kg; IV; single) causes rapid recovery from bradycardia[2].
Pharmacokinetic Parameters of Lerisetron in Sprague-Dawley rats[2].

IV (50 μg/kg)IV (100 μg/kg)IV (200 μg/kg)
CL (L/min)0.0050.0040.004
Vds (L)0.90.880.96
MRT0-LAST (min)224337.1226.3
AUC∞ (μg·min/L)66.157.758.1

References

[1] Orjales A, Mosquera R, Labeaga L, Rodes R. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. J Med Chem. 1997;40(4):586-593.
[2] Jauregizar N, Calvo R, Suarez E, Quintana A, Raczka E, Lukas JC. Pharmacokinetics and pharmacological effect of lerisetron, a new 5-HT3 antagonist, in rats. J Pharm Sci. 2002;91(1):41-52. DOI:10.1002/jps.1169

Lerisetron synthesis

4857-06-1
143257-98-1
Synthesis of Lerisetron from 2-Chlorobenzimidazole

Lerisetron Preparation Products And Raw materials

Raw materials

2-CHLORO-1-(PHENYLMETHYL)-BENZIMIDAZOLE 2-Chlorobenzimidazole Piperazine Benzyl bromide

Preparation Products

Lerisetron Suppliers

Global( 27)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 2028 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3069 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19103 58
Wuhan chuang he chemical co. LTD 15907120073 1261789306@qq.com China 1186 58
Shandong Jirun Biomedical Technology Co., Ltd. 0539-0539-8613587 17661611089 2639273505@qq.com China 182 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
Wuhan chuang he chemical co. LTD 58
Shandong Jirun Biomedical Technology Co., Ltd. 58

View Lastest Price from Lerisetron manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lerisetron pictures 2024-11-19 Lerisetron
143257-98-1
 US $60.00-198.00 / mg 99.15% 10g TargetMol Chemicals Inc.
  • Lerisetron pictures
  • Lerisetron
    143257-98-1
  • US $60.00-198.00 / mg
  • 99.15%
  • TargetMol Chemicals Inc.

Lerisetron Spectrum

Lerisetron(143257-98-1)1HNMR

143257-98-1(Lerisetron)Related Search:

ONDANSETRON FOR LC SYSTEM SUITABILITY Palonosetron ALOSETRON dolasetron Dolasetron mesylate
Granisetron Palonosetron Hydrochloride Palonosetron 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE 1-BENZYL-2-(4-BENZYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOLE
Lerisetron 1-BENZYL-2-(4-METHYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE ZERENEX EZX001545 1-BENZYL-2-(4-PHENYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOLE

1of3

Lerisetron 1-benzyl-2-piperazin-1-yl-1H-benzimidazole dihydrochloride 1-benzyl-2-piperazin-1-ylbenzimidazole F-0930-RS 1-BENZYL-2-PIPERAZIN-1-YL-1H-BENZIMIDAZOLE CID 65997 1H-Benzimidazole, 1-(phenylmethyl)-2-(1-piperazinyl)- 5-HT Receptor,Serotonin Receptor,Serotonin,Lerisetron,Bradycardia,Inhibitor,5-hydroxytryptamine Receptor,Pharmacokinetics,inhibit,SD rats 1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole Lerisetron, 10 mM in DMSO 1-Benzyl-2-(piperazin-1-yl)-1H-1,3-benzodiazole 143257-98-1 C18H22Cl2N4