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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate structure

CAS No.: 571188-59-5

Chemical Name:: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Synonyms: 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;Ribociclib-2;PALBOCICLIB4;Palbociclib-11

CBNumber:: CB62464781

Molecular Formula:: C14H22N4O2

Molecular Weight:: 278.35

MDL Number:: MFCD11594962

MOL File:: 571188-59-5.mol

MSDS File:: SDS

Last updated:2024-08-13 17:19:14

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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Properties

Melting point	130-132℃
Boiling point	454.1±45.0 °C(Predicted)
Density	1.182
vapor pressure	0-0Pa at 20-25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Very Slightly)
form	Solid
pka	7.36±0.26(Predicted)
color	Dark Yellow
Sensitive	Air Sensitive
InChI	InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
InChIKey	RMULRXHUNOVPEI-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
LogP	1.6-1.8 at 35℃ and pH7-9
FDA UNII	6Y3BU8W3TC

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933599590

NFPA 704

	0
2		0

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B4669	tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T)	571188-59-5	200mg	$66	2024-03-01	Buy
TCI Chemical	B4669	tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T)	571188-59-5	1g	$239	2024-03-01	Buy
Alfa Aesar	H54315	4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%	571188-59-5	1g	$170.65	2024-03-01	Buy
Alfa Aesar	H54315	4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%	571188-59-5	5g	$673.65	2024-03-01	Buy
Alfa Aesar	H54315	4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%	571188-59-5	250mg	$57.6	2021-12-16	Buy

Product number	Packaging	Price	Buy
B4669	200mg	$66	Buy
B4669	1g	$239	Buy
H54315	1g	$170.65	Buy
H54315	5g	$673.65	Buy
H54315	250mg	$57.6	Buy

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Uses,Production

Physical Form

Solid

Description

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Uses

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Preparation

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.

Hazard

Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate synthesis

Synthesis of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate from 2-Aminopyridine and 1-BOC-Piperazine

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 1-BOC-Piperazine 2-Amino-5-iodopyridine

Preparation Products

Pyrido[2,3-d]pyriMidine-6-carboxylic acid, 8-cyclopentyl-2-[[5-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]aMino]-7,8-dihydro-5-Methyl-7-oxo-, ethyl ester

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Suppliers

Global( 578)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Qiwei Pharmatech Co.,Ltd	13282840061	mw@qwpharmatech.com	China	109	58
ChemExpress	+86-021-58950125 +86-021-58950125;	info@chemexpress.com	China	737	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-0531-69954981 +8615666777973	dwyane.wang@boyuanpharm.com	China	211	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	255	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	+8618627948422	sale@hdimpurity.com	China	3389	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55

Supplier	Advantage
Hangzhou Qiwei Pharmatech Co.,Ltd	58
ChemExpress	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
Finetech Industry Limited	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-26	Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2024-11-25	Palbociclib side chain 571188-59-5	US $0.00-0.00 / Kg/Bag	2Kg/Bag	0.98	20 tons	Sinoway Industrial co., ltd.
2024-11-22	tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

Palbociclib side chain
571188-59-5
US $0.00-0.00 / Kg/Bag
0.98
Sinoway Industrial co., ltd.

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Spectrum

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate(571188-59-5)¹HNMR

571188-59-5(tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate)Related Search:

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1-N-BOC-4-BROMOPIPERIDINE Copper(II) chloride dihydrate Iodomethane sacubitril

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PD 0332991 HCl 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester LEE011 (succinate)

2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- LEE011 (hydrochloride) 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA

Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- Palbociclib tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate

1of4

1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester tert-butyl 4-(6-aMinopyri 4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic 4-(6-AMinopyridin-3-yl)-1-Boc-piperazine tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib) Palbociclib's intermediate 4-(6-aMinopyridin-3-yl)p t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate) Palbociclib Intermediate Ribociclib-2 tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate 4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate PALBOCICLIB4 2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98% 1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine Palbociclib Impurity 68 Palbociclib-018 Palbociclib-11 Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate POB02 OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5) 4-(6-Amino-3-pyridyl)-1-Boc-piperazine 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate > 4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester )piperazine-1-carboxyL Ribociclib Related Compound 1 Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate 4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE OTAVA-BB 1207229 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate OTAVA-BB 1-Boc-4-(6-amino-3-pyridyl)piperazine 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Palbociclib side chain 4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate 571188-59-5 571188-59-9 PD 0332991 Palbociclib Anticancer 571188-59-5