Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>E3 ligase Ligand-Linker Conjugates 7 Free Base

E3 ligase Ligand-Linker Conjugates 7 Free Base

E3 ligase Ligand-Linker Conjugates 7 Free Base Structure
E3 ligase Ligand-Linker Conjugates 7 Free Base structure
CAS No.
2010159-57-4
Chemical Name:
E3 ligase Ligand-Linker Conjugates 7 Free Base
Synonyms
VH032-PEG4-NH2;PROTACs Related Compound 8;VHL Ligand-Linker Conjugates 4;(S,R,S)-AHPC-PEG?-NH? hydrochloride;(S,R. S)-AHPC-PEG4-amine hydrochloride salt;E3 ligase Ligand-Linker Conjugates 7 Free Base;(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7);L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide
CBNumber:
CB74797053
Molecular Formula:
C32H49N5O8S
Molecular Weight:
663.83
MDL Number:
MFCD31656715
MOL File:
2010159-57-4.mol
Last updated:2024-11-19 23:02:33
Request For Quotation

E3 ligase Ligand-Linker Conjugates 7 Free Base Properties

Boiling point 901.7±65.0 °C(Predicted)
Density 1.230±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in Water, DMSO, Methanol
pka 13.54±0.46(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934100090

E3 ligase Ligand-Linker Conjugates 7 Free Base price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 901848 (S,R,S)-AHPC-PEG4-NH2 hydrochloride ≥95% 2010159-57-4 50mg $452 2024-03-01 Buy
BroadPharm BP-24446 (S,R.S)-AHPC-PEG4-aminehydrochloridesalt 98% 2010159-57-4 250mg $960 2021-12-16 Buy
DC Chemicals 027595 (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7) 2010159-57-4 003 $1000 2021-12-16 Buy
DC Chemicals 027595 (S,R,S)-AHPC-PEG4-NH2(E3ligaseLigand-LinkerConjugates7) 2010159-57-4 002 $500 2021-12-16 Buy
Product number Packaging Price Buy
901848 50mg $452 Buy
BP-24446 250mg $960 Buy
027595 003 $1000 Buy
027595 002 $500 Buy

E3 ligase Ligand-Linker Conjugates 7 Free Base Chemical Properties,Uses,Production

Description

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG4-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 7 Free Base Preparation Products And Raw materials

Raw materials

Preparation Products

E3 ligase Ligand-Linker Conjugates 7 Free Base Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4825 58
Jiangsu aikang biomedical research and development co., LTD 025-66110311 13155353615 qzhang@aikonchem.com China 15527 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1458 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Xian confluore Biological Technology Co., Ltd. 		58
Aladdin Scientific 		58
Sigma-Aldrich 80
Xi'an Confluore Biological Technology Co., Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58
Jilin Province Woda Biotechnology Co., Ltd. 58
DC Chemicals 58

View Lastest Price from E3 ligase Ligand-Linker Conjugates 7 Free Base manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-PEG4-NH2 pictures 2024-11-19 (S,R,S)-AHPC-PEG4-NH2
2010159-57-4
 US $38.00-118.00 / mg 94.31% 10g TargetMol Chemicals Inc.
(S,R,S)-AHPC-PEG4-NH2 pictures 2024-04-02 (S,R,S)-AHPC-PEG4-NH2
2010159-57-4
 US $0.00 / mg 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.

2010159-57-4(E3 ligase Ligand-Linker Conjugates 7 Free Base)Related Search:

E3 ligase Ligand-Linker Conjugates 50 E3 Ligase Ligand-Linker Conjugates 21 E3 ligase Ligand-Linker Conjugates 13 E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate E3 ligase Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 6 E3 Ligase Ligand-Linker Conjugates 19 E3 Ligase Ligand-Linker Conjugates 22 E3 ligase Ligand-Linker Conjugates 11

1of2

E3 ligase Ligand-Linker Conjugates 7 Free Base VH032-PEG4-NH2 VHL Ligand-Linker Conjugates 4 PROTACs Related Compound 8 (S,R. S)-AHPC-PEG4-amine hydrochloride salt L-Prolinamide, N-(14-amino-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (2S,4R)-1-[(S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide (2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate (S,R,S)-AHPC-PEG?-NH? hydrochloride (2s,4R)-1-[(2s)-2-[[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]acetyl]amino]-3.3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide (2S,4R)-1-[(2S)-2-(14-amino-3,6,9,12-tetraoxatetradecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide 2010159-57-4 C32H49N5O8S