ChemicalBook >> CAS DataBase List >>E3 ligase Ligand-Linker Conjugates 50
E3 ligase Ligand-Linker Conjugates 50
- CAS No.
- 2271036-44-1
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 50
- Synonyms
- Poma-PEG1-N3;Pomalidomide-PEG1-C2-N3;Cereblon Ligand-Linker Conjugates 13;E3 ligase Ligand-Linker Conjugates 50;4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- CBNumber:
- CB96127047
- Molecular Formula:
- C17H18N6O5
- Molecular Weight:
- 386.37
- MDL Number:
- MFCD32197214
- MOL File:
- 2271036-44-1.mol
Last updated:2024-07-02 08:55:42
E3 ligase Ligand-Linker Conjugates 50 Chemical Properties,Uses,Production
Biological Activity
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
storage
Store at -20°C
References
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
E3 ligase Ligand-Linker Conjugates 50 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 50 Suppliers
Global( 21)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9929 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1382 | 58 |
| Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD | 025-86755008 17751752005 | hszhang@bestfluorodrug.com | China | 2358 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 54986 | 58 |
| Zhengzhou Convergence Chemical Co. LTD | 0371-53736046 13393710386 | 2853979814@qq.com | China | 9989 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7966 | 58 |
2271036-44-1(E3 ligase Ligand-Linker Conjugates 50)Related Search:
Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3
Pomalidomide-PEG6-butyl iodide
1of4
E3 ligase Ligand-Linker Conjugates 50
Cereblon Ligand-Linker Conjugates 13
Pomalidomide-PEG1-C2-N3
4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Poma-PEG1-N3
2271036-44-1