D-Alanine
- CAS No.
- 338-69-2
- Chemical Name:
- D-Alanine
- Synonyms
- D-ALA;H-D-ALA-OH;(R)-2-aMinopropanoic acid;D-alaine;(R)-Alanine;D-ALPHA-ALANINE;D-AL;Canef;Cranoc;Vastin
- CBNumber:
- CB7783360
- Molecular Formula:
- C3H7NO2
- Molecular Weight:
- 89.09
- MDL Number:
- MFCD00008077
- MOL File:
- 338-69-2.mol
- MSDS File:
- SDS
| Melting point | 291 °C (dec.)(lit.) |
|---|---|
| Boiling point | 212.9±23.0 °C(Predicted) |
| alpha | -14.5 º (c=10, 6N HCl) |
| Density | 1.4310 (estimate) |
| refractive index | -14 ° (C=2, 6mol/L HCl) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble |
| form | Crystalline Powder or Crystals |
| pka | 2.31±0.10(Predicted) |
| color | White to off-white |
| Odor | odorless |
| Water Solubility | 155 g/L (20 ºC) |
| Merck | 14,204 |
| BRN | 1720249 |
| LogP | -0.574 (est) |
| CAS DataBase Reference | 338-69-2(CAS DataBase Reference) |
| FDA UNII | E3UDS4613U |
| NIST Chemistry Reference | D-Alanine(338-69-2) |
| EPA Substance Registry System | D-Alanine (338-69-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29224995 | |||||||||
| NFPA 704 |
|
D-Alanine price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7377 | D-Alanine ≥98% (HPLC) | 338-69-2 | 5g | $55.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | A7377 | D-Alanine ≥98% (HPLC) | 338-69-2 | 25g | $190 | 2024-03-01 | Buy |
| TCI Chemical | A0177 | D-Alanine >98.0%(T) | 338-69-2 | 5g | $29 | 2024-03-01 | Buy |
| TCI Chemical | A0177 | D-Alanine >98.0%(T) | 338-69-2 | 25g | $82 | 2024-03-01 | Buy |
| Alfa Aesar | A10231 | D-Alanine, 99% | 338-69-2 | 5g | $38.8 | 2024-03-01 | Buy |
D-Alanine Chemical Properties,Uses,Production
Chemical Properties
A white crystalline Powder with no peculiar smell and a sweet taste. It is easily soluble in water, slightly soluble in ethanol, and insoluble in acetone and ether. The decomposition point is 297°C. The specific rotation is [α]25D -1.8° (0.5–2.0 mg/ml, H2O) and [α]25D -14.6° (0.5–2.0 mg/ml, 5 mol/L HCl).
Uses
D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.
Definition
ChEBI: D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.
Preparation
D-Alanine can be obtained by hydrolysis and refining of proteins such as gelatin, sericin and corn protein, or it can be synthesized by chemical methods.
Application
D-Alanine is a LHRH-antagonists, e.g., Abarelix (antineoplas- tic)
General Description
Alanine is a non essential amino acid.
Biochem/physiol Actions
D-Alanine is the non-proteinogenic form of alanine which is used in bacterial cell wall biosynthesis. D-Alanine is used to study the specificity and kinetics of alanine racemase(s) (alaR).
Purification Methods
Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]
References
[1] ISAO UMEMURA. d-Alanine production from dl-alanine by Candida maltosa with asymmetric degrading activity[J]. Applied Microbiology and Biotechnology, 1992, 36 6: 722-726. DOI:10.1007/BF00172182.
[2] TIAN (AUTUMN) QIU. Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice[J]. Communications Biology, 2023: 1-11. DOI:10.1038/s42003-023-05209-y.
[3] AMIT PRIYADARSHI . Structural insights into the alanine racemase from Enterococcus faecalis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2009, 1794 7: Pages 1030-1040. DOI:10.1016/j.bbapap.2009.03.006.
[4] CINDY J. LEE Jonathan V S Tian A Qiu. d-Alanine: Distribution, origin, physiological relevance, and implications in disease[J]. Biochimica et biophysica acta. Proteins and proteomics, 2020, 1868 11: Article 140482. DOI:10.1016/j.bbapap.2020.140482.
D-Alanine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7688 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18151 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3009 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29793 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9004 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Related articles
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- Dec 6，2024
View Lastest Price from D-Alanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-03 | D-Alanine
338-69-2
|
US $0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2025-01-03 | D-Alanine
338-69-2
|
US $120.00 / kg | 1kg | 99% | 10ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-01-02 | D-alanine
338-69-2
|
US $70.00 / kg | 1kg | 0.98 | 25kg | Shanghai UCHEM Inc. |
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