Fluanisone
- CAS No.
- 1480-19-9
- Chemical Name:
- Fluanisone
- Synonyms
- R 2028;R 2167;2028 Md;MD 2028;Fluanison;Anti-pica;Sedalande;Fluanisone;Haloanison;NSC 170977
- CBNumber:
- CB7875027
- Molecular Formula:
- C21H25FN2O2
- Molecular Weight:
- 356.43
- MDL Number:
- MFCD00366636
- MOL File:
- 1480-19-9.mol
Melting point | 67.5-68.5° |
---|---|
Boiling point | 511.8±50.0 °C(Predicted) |
Density | 1.146 |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 7.43±0.10(Predicted) |
form | Solid |
color | Off-White to Pale Yellow |
FDA UNII | 1D0W98U1I4 |
ATC code | N05AD09 |
Fluanisone price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Usbiological | 012092 | Fluanisone | 1480-19-9 | 50mg | $460 | 2021-12-16 | Buy |
TRC | F406800 | Fluanisone | 1480-19-9 | 1g | $1420 | 2021-12-16 | Buy |
TRC | F406800 | Fluanisone | 1480-19-9 | 2g | $2605 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0015262 | FLUANISONE 95.00% | 1480-19-9 | 5MG | $496.31 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 58057 | Fluanisone | 1480-19-9 | 50mg | $650 | 2021-12-16 | Buy |
Fluanisone Chemical Properties,Uses,Production
Originator
Sedalande ,J and J
Uses
Fluanisone is a neuroleptic with sedative properties and relatively poorly expressed antipsychotic action. It is used as an independent or adjuvant drug for psychomotor excitement in severe and chronic schizophrenia and for manic-depressive disorder.
Uses
Fluanisone is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia.
Definition
ChEBI: Fluanisone is an aromatic ketone.
Manufacturing Process
To a suspension of 341 parts of aluminum chloride in 1740 parts of carbon
disulfide are added 96 parts of fluorobenzene with stirring and cooling. While
the temperature is maintained at about 10°C, 141 parts of γ-chlorobutyryl
chloride are added. After the addition is completed, the cooling bath is
removed and the stirring is continued for 2 hours. The reaction mixture is
poured into ice water. The organic layer is separated, washed with water, dried
over anhydrous sodium sulfate, and filtered. The filtrate is concentrated under
reduced pressure, and the residue is distilled to yield γ-chloro-p-fluorobutyrophenone
boiling at about 136°-142°C/6 mm
A mixture of 6.6 parts of γ-chloro-p-fluoro-butyrophenone and 12.5 parts of 1-
(o-anisyl)piperazine is heated for 10 hours at a temperature of 110°C. The
reaction mixture is treated with 800 parts of ether and filtered. The ether
layer is washed with water, dried over anhydrous potassium carbonate and
filtered, whereupon hydrogen chloride gas is introduced into the solution. The
precipitate is collected on a filter and dissolved in a mixture of 240 parts of 2-
propanol and 80 parts of acetone to yield 1-[γ-(p-fluorobenzoyl)propyl]-4-(o-anisyl)piperazine hydrochloride. This monohydrochloride is collected on a filter
and dissolved in 240 parts of 2-propanol. Anhydrous, gaseous hydrogen
chloride is passed through the solution. On cooling, the 1-[γ-(p-fluorobenzoyl)
propyl]-4-(o-anisyl)piperazine dihydrochloride precipitates.
A second crop of product is obtained by passing hydrogen chloride gas
through the solution of mother liquors. The pale-brown, amorphous powder is
collected on a filter and found to melt at about 205°-205.5°C.
This salt is dissolved in water and treated with sodium hydroxide. The
precipitated base is recovered by filtration and recrystallized from diisopropyl
ether. The white crystals melt at about 67.5°-68.5°C.
Therapeutic Function
Neuroleptic
Synthesis
Fluanisone, 4??-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]-butyrophenone (6.3.12), is synthesized by reacting 1-(2??-methoxyphenyl)-piperazine with 4-chloro- 4??-fluorobutyrophenone (6.3.4) [50].
Fluanisone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 6011 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5840 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 | admin@flanderff.com | China | 225 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29897 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12460 | 58 |
Hebei Runbin Biotechnology Co. LTD | 13180553332 | 2179877681@qq.com | CHINA | 996 | 58 |
View Lastest Price from Fluanisone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-07-26 | Fluanisone
1480-19-9
|
US $19.00 / KG | 1KG | 99.% | 50 ton | Hebei Guanlang Biotechnology Co,.LTD | ||
2024-03-27 | fluanisone
1480-19-9
|
US $20.00 / kg | 1kg | 99 | 1000kg | Shaanxi Franta Biotechnology Co., Ltd | ||
2024-01-18 | fluanisone
1480-19-9
|
US $15.00 / kg | 1kg | 99% | large quantity | Xiamen Wonderful Bio Technology Co., Ltd. |
- Fluanisone
1480-19-9
- US $19.00 / KG
- 99.%
- Hebei Guanlang Biotechnology Co,.LTD
- fluanisone
1480-19-9
- US $20.00 / kg
- 99
- Shaanxi Franta Biotechnology Co., Ltd
- fluanisone
1480-19-9
- US $15.00 / kg
- 99%
- Xiamen Wonderful Bio Technology Co., Ltd.