Malotilate
- CAS No.
- 59937-28-9
- Chemical Name:
- Malotilate
- Synonyms
- DDYM;Kantec;nkk105;cl-1500;Hepation;MaIotilate;MALOTILATE;MALOTILATUM;Malotilate >Malotilate, BR
- CBNumber:
- CB8227928
- Molecular Formula:
- C12H16O4S2
- Molecular Weight:
- 288.38
- MDL Number:
- MFCD00867646
- MOL File:
- 59937-28-9.mol
| Melting point | 60.5° |
|---|---|
| Boiling point | 400.61°C (rough estimate) |
| Density | 1.3727 (rough estimate) |
| refractive index | 1.4950 (estimate) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol,Ether,Benzene |
| form | powder to crystal |
| color | White to Light yellow |
| Merck | 14,5712 |
| CAS DataBase Reference | 59937-28-9(CAS DataBase Reference) |
| FDA UNII | RV59PND975 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362 |
| RTECS | OO0970000 |
| HS Code | 2934.99.4700 |
Malotilate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2674 | Malotilate >98.0%(GC) | 59937-28-9 | 1g | $121 | 2024-03-01 | Buy |
| TCI Chemical | M2674 | Malotilate >98.0%(GC) | 59937-28-9 | 5g | $363 | 2024-03-01 | Buy |
| Cayman Chemical | 30266 | Malotilate | 59937-28-9 | 1g | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 30266 | Malotilate | 59937-28-9 | 5g | $270 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0003245 | MALOTILATE 95.00% | 59937-28-9 | 5G | $327.6 | 2021-12-16 | Buy |
Malotilate Chemical Properties,Uses,Production
Description
Malotilate is a hepatoprotective agent reported to be effective in the treatment of cirrhosis, chronic hepatitis and similar liver disorders. It appears to improve hepatic function by increasing blood and bile flow and improving protein synthesis.
Description
Malotilate is a hepatoprotective agent. It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; ) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury. It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.
Originator
Nihon Nohyaku (Japan)
Definition
ChEBI: Malotilate is an isopropyl ester.
brand name
KANTEC
in vitro
the in-vitro invasion assay employing a rat lung endothelial cell monolayer indicated that pretreatment of the lung endothelial cells, but not c-sst-2 cells, with malotilate reduced the invasion of the rle monolayer by c-sst-2 cells significantly. the in-vitro vascular permeability assay also demonstrated malotilate could prevent the permeability increase of the lung endothelial cell monolayer by serum starvation. in contrast, the gelatinase production and adhesion to the rle cell monolayer of c-sst-2 cells were not affected by malotilate treatment [1].
in vivo
malotilate was administered to syngeneic shr rats orally from 7 days before or after s.c. inoculation of c-sst-2 cells until the end of the experiments. in the malotilate-treated rats, pulmonary metastasis was suppressed markedly when compared with the non-treated rats. moreover, in the rats treated with malotilate for 19 days after inoculation of c-sst-2 cells, lung metastasis was also suppressed significantly [1].
References
[1] nagayasu h,hamada j,kawano t,konaka s,nakata d,shibata t,arisue m,hosokawa m,takeichi n,moriuchi t. inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. br j cancer.1998 may;77(9):1371-7.
[2] takase s,matsuda y,yasuhara m,takada a. effects of malotilate treatment on alcoholic liver disease. alcohol.1989 may-jun;6(3):219-22.
Malotilate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6383 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32200 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7859 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15393 | 58 |
View Lastest Price from Malotilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Malotilate
59937-28-9
|
US $0.00 / Kg/Bag | 1KG | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Malotilate
59937-28-9
|
US $45.00-91.00 / mg | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Malotilate
59937-28-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Malotilate
59937-28-9
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Malotilate
59937-28-9
- US $45.00-91.00 / mg
- 99.98%
- TargetMol Chemicals Inc.
-
- Malotilate
59937-28-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd