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WAY-255348

WAY-255348 Structure
WAY-255348 structure
CAS No.
872141-23-6
Chemical Name:
WAY-255348
Synonyms
WAY-255348;5-(7-fluoro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile;5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methy l-1H-pyrrole-2-carbonitrile;1H-Pyrrole-2-carbonitrile, 5-(7-fluoro-2,3-dihydro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methyl-
CBNumber:
CB82628527
Molecular Formula:
C16H14FN3O
Molecular Weight:
283.3
MDL Number:
MFCD18782604
MOL File:
872141-23-6.mol
Last updated:2023-05-07 08:29:00
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WAY-255348 Properties

Boiling point 467.1±45.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
pka 12.77±0.40(Predicted)

WAY-255348 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0014191 WAY-255348 95.00% 872141-23-6 5MG $496.34 2021-12-16 Buy
Product number Packaging Price Buy
API0014191 5MG $496.34 Buy

WAY-255348 Chemical Properties,Uses,Production

Description

WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.

WAY-255348 synthesis

868744-62-1
872141-26-9
872141-23-6
Synthesis of WAY-255348 from 1H-Pyrrole-2-carbonitrile, 1-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)- and 2H-Indol-2-one, 5-bromo-7-fluoro-1,3-dihydro-3,3-dimethyl-

WAY-255348 Preparation Products And Raw materials

Raw materials

1H-Pyrrole-2-carbonitrile, 1-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)- 2H-Indol-2-one, 5-bromo-7-fluoro-1,3-dihydro-3,3-dimethyl- 5-cyano-1-methyl-1H-pyrrol-2-ylboronic acid

Preparation Products

WAY-255348 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou ARTK Medchem Co., Ltd. 		+8618168183658 sales1@artkmedchem.com China 39009 58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. +86-13857751219; 15720605021 zhang_lei@jsnchem.com China 1549 58
PharmaBlock Sciences (Nanjing), Inc. 4000255188 sun_dan@PharmaBlock.com China 7268 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28118 58
Supplier Advantage
Suzhou ARTK Medchem Co., Ltd. 		58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. 58
PharmaBlock Sciences (Nanjing), Inc. 58
TargetMol Chemicals Inc. 58
WAY-255348 5-(7-fluoro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile 1H-Pyrrole-2-carbonitrile, 5-(7-fluoro-2,3-dihydro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methyl- 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methy l-1H-pyrrole-2-carbonitrile 872141-23-6