Ethyl trifluoropyruvate
- CAS No.
- 13081-18-0
- Chemical Name:
- Ethyl trifluoropyruvate
- Synonyms
- ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%;Ethyl-trifluoroMethylpyruvate
- CBNumber:
- CB8333735
- Molecular Formula:
- C5H5F3O3
- Molecular Weight:
- 170.09
- MDL Number:
- MFCD00114935
- MOL File:
- 13081-18-0.mol
- MSDS File:
- SDS
| Boiling point | 42 °C(lit.) |
|---|---|
| Density | 1.283 g/mL at 25 °C (lit.) |
| vapor pressure | 12.49hPa at 25℃ |
| refractive index |
n |
| Flash point | 88 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Miscible with dichloromethane. |
| form | Liquid |
| color | Clear colorless to pale yellow |
| BRN | 2087388 |
| Stability | Moisture Sensitive |
| InChIKey | KJHQVUNUOIEYSV-UHFFFAOYSA-N |
| LogP | -0.05 |
| CAS DataBase Reference | 13081-18-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P233-P240-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,C,Xi | |||||||||
| Risk Statements | 10-22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-16 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
Ethyl trifluoropyruvate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 510254 | Ethyl 3,3,3-trifluoropyruvate 97% | 13081-18-0 | 5g | $26 | 2024-03-01 | Buy |
| TCI Chemical | T1434 | Ethyl Trifluoropyruvate >98.0%(GC) | 13081-18-0 | 5g | $47 | 2024-03-01 | Buy |
| TCI Chemical | T1434 | Ethyl Trifluoropyruvate >98.0%(GC) | 13081-18-0 | 25g | $135 | 2024-03-01 | Buy |
| Alfa Aesar | B20611 | Ethyl trifluoropyruvate, 97% | 13081-18-0 | 5g | $46.65 | 2024-03-01 | Buy |
| Alfa Aesar | B20611 | Ethyl trifluoropyruvate, 97% | 13081-18-0 | 25g | $184 | 2024-03-01 | Buy |
Ethyl trifluoropyruvate Chemical Properties,Uses,Production
Chemical Properties
Clear pale yellow liquid
Uses
Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters.
Uses
Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.
Uses
Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .
General Description
Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.
Synthesis
To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.
Ethyl trifluoropyruvate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 57 | 55 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
View Lastest Price from Ethyl trifluoropyruvate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-11 | Ethyl trifluoropyruvate
13081-18-0
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2022-09-17 | Ethyl trifluoropyruvate
13081-18-0
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2020-11-16 | Ethyl trifluoropyruvate
13081-18-0
|
US $50.00 / KG | 1KG | 99% | 10000KG | Longyan Tianhua Biological Technology Co., Ltd |
-
- Ethyl trifluoropyruvate
13081-18-0
- US $9.00 / KG
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Ethyl trifluoropyruvate
13081-18-0
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Ethyl trifluoropyruvate
13081-18-0
- US $50.00 / KG
- 99%
- Longyan Tianhua Biological Technology Co., Ltd