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DMT-2′Fluoro-dU Phosphoramidite

DMT-2′Fluoro-dU Phosphoramidite structure

CAS No.: 146954-75-8

Chemical Name:: DMT-2′Fluoro-dU Phosphoramidite

Synonyms: 2‘-F-U amidite;2'-Fluoro-dU CEP;2’-F-dU Amidite;2’-F-rUPhosphoramidite;2'-F-U Phosphoramidite;2'-F-dU Phosphoramidite;5'-O-DMT-2'-fluoro-dU-CE;5'-O-DMT-2'-F-dU-3'-CEDPA;2'-Fluoro Uridine Amidite;2'-Fluoro Uridine Amidite

CBNumber:: CB8500324

Molecular Formula:: C39H46FN4O8P

Molecular Weight:: 748.78

MDL Number:: MFCD11113919

MOL File:: 146954-75-8.mol

MSDS File:: SDS

Last updated:2024-11-20 11:41:24

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DMT-2′Fluoro-dU Phosphoramidite Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
form	powder
pka	9.39±0.10(Predicted)
color	white to off-white
InChIKey	HQHQPAYRJJMYQX-YOKGOYKLNA-N
SMILES	N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F \|&1:8,10,36,51,r\|

SAFETY

Risk and Safety Statements

WGK Germany	3

DMT-2′Fluoro-dU Phosphoramidite price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	1G	$206	2024-03-01	Buy
Sigma-Aldrich	U211250	DMT-2′Fluoro-dU Phosphoramidite configured for (?KTA? and OligoPilot?)	146954-75-8	1G	$219	2024-03-01	Buy
Sigma-Aldrich	U211200	DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR)	146954-75-8	100g	$8200	2024-03-01	Buy
Sigma-Aldrich	U211200	DMT-2′Fluoro-dU Phosphoramidite ≥99% (31P-NMR)	146954-75-8	500g	$36650	2024-03-01	Buy
Sigma-Aldrich	U211280	DMT-2′Fluoro-dU Phosphoramidite configured for PerkinElmer, configured for Polygen	146954-75-8	2g	$383	2024-03-01	Buy

Product number	Packaging	Price	Buy
U211280	1G	$206	Buy
U211250	1G	$219	Buy
U211200	100g	$8200	Buy
U211200	500g	$36650	Buy
U211280	2g	$383	Buy

DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Uses,Production

Uses

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.

Definition

DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA

Synthesis

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).

DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2′Fluoro-dU Phosphoramidite Suppliers

Global( 168)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Allbiosyn Biotechnology Co.,Ltd.	+8618666985712	info@allbiosyn.com	China	286	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Allbiosyn Biotechnology Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Yunbio Tech Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from DMT-2′Fluoro-dU Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	DMT-2′Fluoro-dU Phosphoramidite 146954-75-8	US $39.00 / mL		98.45%	10g	TargetMol Chemicals Inc.
2024-08-08	5'-O-DMT-2'-fluoro-dU-CE 146954-75-8	US $0.00 / mg	100mg	≥99%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2024-02-13	5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 146954-75-8	US $1550.00 / g	1g	98	500 Kg	R&D Scientific Inc.

DMT-2′Fluoro-dU Phosphoramidite
146954-75-8
US $39.00 / mL
98.45%
TargetMol Chemicals Inc.

5'-O-DMT-2'-fluoro-dU-CE
146954-75-8
US $0.00 / mg
≥99%
Hefei Huana Biomedical Technology Co.,Ltd.

5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit
146954-75-8
US $1550.00 / g
98
R&D Scientific Inc.

146954-75-8(DMT-2′Fluoro-dU Phosphoramidite)Related Search:

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DMT-2'O-Methyl-rU Phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite DMT-dG(dmf) Phosphoramidite 3'-TBDMS-ibu-rG Phosphoramidite Ac-rC Phosphoramidite

Uridine DMT-2′Fluoro-dU Phosphoramidite

1of4

2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-DMT-2'-F-rU Phosphoramidite DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE DMT-2'-F-dU Amidite 0.25g, 89, Single 2’-F-rUPhosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-F-dU-3'-CEDPA 2'-F-dU Phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite DMT-2′Fluoro-dU Phosphoramidite 3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite 2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite 5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite 2'-Fluoro-dU CEP Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 5'-Dimethoxytrityl-deoxyUridine, 2'-fluoro-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite 2'-Fluoro-N2-Isobutyryl-5'-O-DMT-2'-Deoxyguanosine-3'-CE-Phosphoramidite 5'-DMTr-2'-F-3'-O-CEP-URIDINE 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 2‘-F-U amidite DMT-2'-F-U Phosphoramidite DMT-2’-F-dU-CE Phosphoramidite 5'-O-DMT-2'-fluoro-dU-CE Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro Uridine Amidite 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile DMTr-2'-F-dU-3'-CE-Phosphoramidite 2’-F-dU Amidite 5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite 5'-ODMT-2'-Fluoro uridine-3'-OCEPA 2'-F-U Phosphoramidite DMT-2'-F-dU-CE Phosphoramidite 5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidit 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite 2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite DMTr-2'-F-dU-3'-CE-Phosphoramidite 5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite 2'-Fluoro Uridine Amidite DMT-2'FLUORO-DU PHOSPHORAMIDITE Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite 146954-75-8 Amidite