etomidoline
- CAS No.
- 21590-92-1
- Chemical Name:
- etomidoline
- Synonyms
- Nonspa;K 2680;Smedolin;Amidoline;etomidoline;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
- CBNumber:
- CB8896360
- Molecular Formula:
- C23H29N3O2
- Molecular Weight:
- 379.5
- MDL Number:
- MFCD00867691
- MOL File:
- 21590-92-1.mol
| Melting point | 106-107° |
|---|---|
| Boiling point | 507.34°C (rough estimate) |
| Density | 1.1315 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| pka | 8.75±0.10(Predicted) |
| FDA UNII | WFS7G78GYJ |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971) |
|---|
etomidoline Chemical Properties,Uses,Production
Originator
Smedolin,Yamanouchi,Japan,1976
Definition
ChEBI: Etomidoline is an organic molecular entity.
Manufacturing Process
31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol)
are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution
5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added
and the resulted mixture is heated at 70°C for 1 hour, and then poured into
an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-
isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to
104°C) is obtained as a byproduct with the above compound. This latter
compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.
Therapeutic Function
Muscle relaxant
etomidoline Preparation Products And Raw materials
etomidoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |