에토미돌린

에토미돌린
에토미돌린 구조식 이미지
카스 번호:
21590-92-1
한글명:
에토미돌린
동의어(한글):
에토미돌린
상품명:
etomidoline
동의어(영문):
Nonspa;K 2680;Smedolin;Amidoline;etomidoline;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
CBNumber:
CB8896360
분자식:
C23H29N3O2
포뮬러 무게:
379.5
MOL 파일:
21590-92-1.mol

에토미돌린 속성

녹는점
106-107°
끓는 점
507.34°C (rough estimate)
밀도
1.1315 (rough estimate)
굴절률
1.6500 (estimate)
산도 계수 (pKa)
8.75±0.10(Predicted)

안전

독성 LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971)

에토미돌린 C화학적 특성, 용도, 생산

Originator

Smedolin,Yamanouchi,Japan,1976

Manufacturing Process

31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

Therapeutic Function

Muscle relaxant

에토미돌린 준비 용품 및 원자재

원자재

준비 용품


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