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SINEFUNGIN

SINEFUNGIN structure

CAS No.: 58944-73-3

Chemical Name:: SINEFUNGIN

Synonyms: SF;A-9145;rp32232;32232RP;SINEFUNGIN;Sinefungine;SCF from rat;Steel Factor;compound57926;A 9145, RP 32232

CBNumber:: CB9167377

Molecular Formula:: C15H23N7O5

Molecular Weight:: 381.39

MDL Number:: MFCD00865623

MOL File:: 58944-73-3.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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SINEFUNGIN Properties

alpha	D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water)
Boiling point	783.2±70.0 °C(Predicted)
Density	1.91±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: soluble
form	powder
pka	pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃)
color	white to yellow
biological source	rat
Stability	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
FDA UNII	W2U467CIIL
UNSPSC Code	12352202
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
WGK Germany	3
RTECS	HE3140000
HS Code	29419090
Toxicity	LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.)

SINEFUNGIN price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S8559	Sinefungin 95% (HPLC), powder	58944-73-3	10mg	$640	2024-03-01	Buy
Sigma-Aldrich	SRP3251	SCF from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture	58944-73-3	10μG	$339	2023-06-20	Buy
Cayman Chemical	13829	Sinefungin ≥95%	58944-73-3	500μg	$43	2022-04-27	Buy
Cayman Chemical	13829	Sinefungin ≥95%	58944-73-3	1mg	$77	2022-04-27	Buy
Cayman Chemical	13829	Sinefungin ≥95%	58944-73-3	5mg	$292	2022-04-27	Buy

Product number	Packaging	Price	Buy
S8559	10mg	$640	Buy
SRP3251	10μG	$339	Buy
13829	500μg	$43	Buy
13829	1mg	$77	Buy
13829	5mg	$292	Buy

SINEFUNGIN Chemical Properties,Uses,Production

Description

Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2?IC50?< 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3?Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4?Inhibits biofilm formation by?Streptococcus pneumoniae.5

Uses

Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.

Uses

Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.

Definition

ChEBI: An adenosine that is the the delta-(5'-adenosyl) derivative of ornithine.

General Description

Chemical structure: nucleoside

Biochem/physiol Actions

Probable transcription factor. Plays a critical role in the control of immune response.

References

1) Barbes?et al. (1990),?Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria;? FEMS Microbiol. Lett.,?57?239 2) Yebra?et al. (1991),?The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces;? J. Antibiot. (Tokyo),?44?1141 3) Cheng?et al. (2004),?Small molecule regulators of protein arginine methyltransferases;? J. Biol. Chem.,?279?23892 4) Schluckebier?et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI;? J. Mol. Biol., 265?56 5) Yadav?et al. (2014),?Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth;? Biomed. Res. Int.,?2014?156987

SINEFUNGIN Preparation Products And Raw materials

Raw materials

Preparation Products

SINEFUNGIN Suppliers

Global( 97)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9985	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
NewCan Biotech Limited	58
Nextpeptide Inc	58
Alfa Chemistry	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

View Lastest Price from SINEFUNGIN manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Sinefungin 58944-73-3	US $497.00-129.00 / mg		98.12%	10g	TargetMol Chemicals Inc.

Sinefungin
58944-73-3
US $497.00-129.00 / mg
98.12%
TargetMol Chemicals Inc.

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6,7,8,9-hexadeoxy-yl)-5 6,9-diamino-1-(6-amino-9h-purin-9-d-glycero-alpha-l-talo-decofuranuronicaci 6,9-diamino-1-(6-amino-9h-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronica compound57926 rp32232 SINEFUNGIN 5'-DEOXY-5'-(1,4-DIAMINO-4-CARBOXYBUTYL)ADENOSINE ADENOSYLORNITHINE A-9145 ANTIBIOTIC A-9145 Anti-Foxp3 (C-terminal) antibody produced in rabbit Kit ligand Precursor SCF from rat Mast Cell Growth Factor (MGF) Steel Factor 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decofuranuronic acid InSolution? Sinefungin (2S,5S)-5-(5'-Adenosyl)-2,5-diaminopentanoic acid 32232RP Antibiotic 32232RP Sinefungin,5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP A 9145, RP 32232 (2S,5S)-2,5-Diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid InSolution Sinefungin - CAS 58944-73-3 - Calbiochem D-glycero-α-L-talo-Decofuranuronic acid, 6,9-diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy- D-glycero-a-L-talo-Decofuranuronic acid,6,9-diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy- Sinefungine SF UUP,collagen 3,A 9145,inhibit,H3K4,Antibiotic,Sinefungin,α-SMA,FSP-1,Fungal,Inhibitor,A9145,Histone Methyltransferase,collagen 1 (2S,5S)-2,5-Diamino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)hexanoic acid (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid Sinefungin, methyltransferase inhibitor 58944-73-3 C15H23N7O5 Antibiotics N-S BioChemical Antibiotics A to Z Antibiotics