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Sb-742457

Sb-742457 Structure
Sb-742457 structure
CAS No.
607742-69-8
Chemical Name:
Sb-742457
Synonyms
CS-579;RVT-101;CS-2723;Sb-742457;Sb 742457;Gsk 742457;SB-742457(RVT-101);Sb-742457 USP/EP/BP;SB 742457/GSK 742457;SB742457:Intepirdine
CBNumber:
CB92495263
Molecular Formula:
C19H19N3O2S
Molecular Weight:
353.44
MDL Number:
MFCD12828872
MOL File:
607742-69-8.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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Sb-742457 Properties

Boiling point 608.3±45.0 °C(Predicted)
Density 1.292
storage temp. Store at -20°C
solubility insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
pka 8?+-.0.10(Predicted)
form solid
color Light yellow to yellow
FDA UNII 2IOB2M82HY

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

Sb-742457 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22200 SB-742457 ≥98% 607742-69-8 1mg $37 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 607742-69-8 5mg $169 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 607742-69-8 10mg $319 2024-03-01 Buy
Cayman Chemical 22200 SB-742457 ≥98% 607742-69-8 25mg $704 2024-03-01 Buy
ChemScene CS-1087 Intepirdine 98.92% 607742-69-8 100mg $1100 2021-12-16 Buy
Product number Packaging Price Buy
22200 1mg $37 Buy
22200 5mg $169 Buy
22200 10mg $319 Buy
22200 25mg $704 Buy
CS-1087 100mg $1100 Buy

Sb-742457 Chemical Properties,Uses,Production

Description

SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.

Uses

SB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.

target

5-HT6

References

[1] aaron t. t. chuang, andrew foley, perdita l. pugh, david sunter, xin tong, ciaran regan, lee a. dawson, andrew d. medhurst, neil upton.5-ht6 receptor antagonist sb-742457 as a novel cognitive enhancing agent for alzheimer’s disease. alzheimer's & dementia: the journal of the alzheimer's association volume 2, issue 3, supplement, pages s631–s632, july 2006

Sb-742457 Preparation Products And Raw materials

Raw materials

Preparation Products

Sb-742457 Suppliers

Global( 129)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29881 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58

View Lastest Price from Sb-742457 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Intepirdine pictures 2024-11-19 Intepirdine
607742-69-8
 US $34.00-107.00 / mg 98.99% 10g TargetMol Chemicals Inc.
Sb-742457 pictures 2019-07-06 Sb-742457
607742-69-8
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Intepirdine pictures
  • Intepirdine
    607742-69-8
  • US $34.00-107.00 / mg
  • 98.99%
  • TargetMol Chemicals Inc.
  • Sb-742457 pictures
  • Sb-742457
    607742-69-8
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

Sb-742457 Spectrum

Sb-742457(607742-69-8)1HNMR

607742-69-8(Sb-742457)Related Search:

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SB-705498 SB 203580 SB242235

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Gsk 742457 Sb 742457 Sb-742457 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline SB 742457/GSK 742457 Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)- SB742457:Intepirdine Intepirdine(SB742457) 3-(BENZENESULFONYL)-8-(PIPERAZIN-1-YL)QUINOLINE SB 742457;RVT 101;SB742457;RVT101 CS-579 SB-742457(RVT-101) RVT-101 CS-2723 RVT101. intepirdine. SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. INTEPIRDINE. Sb-742457 USP/EP/BP Intepirdine (SB-742457, RVT-101） Intepirdine HCl (SB-742457 SB 742457/GSK 742457/SB742457 607742-69-8 Inhibitors API