GSK-2126458
- CAS No.
- 1086062-66-9
- Chemical Name:
- GSK-2126458
- Synonyms
- CS-55;GSK458;GSK212;HYR-582;OMipalisib;GSK2126458;GSK-2126458;GSK2126458, >=98%;Omipalisib GSK458;GSK2126458 (GSK458)
- CBNumber:
- CB92505205
- Molecular Formula:
- C25H17F2N5O3S
- Molecular Weight:
- 505.5
- MDL Number:
- MFCD16038929
- MOL File:
- 1086062-66-9.mol
| Melting point | 187-189℃ |
|---|---|
| Boiling point | 715.6±70.0 °C(Predicted) |
| Density | 1.45 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | 6.23±0.40(Predicted) |
| color | White to Pale Yellow |
| FDA UNII | 1X8F5A3NA0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H361fd-H372 | |||||||||
| Precautionary statements | P202-P260-P264-P270-P301+P312-P308+P313 | |||||||||
| HS Code | 29350090 | |||||||||
| NFPA 704 |
|
GSK-2126458 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3161 | GSK2126458 ≥98% (HPLC) | 1086062-66-9 | 10MG | $91.6 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML3161 | GSK2126458 ≥98% (HPLC) | 1086062-66-9 | 50MG | $369 | 2022-05-15 | Buy |
| Cayman Chemical | 17377 | GSK2126458 ≥98% | 1086062-66-9 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17377 | GSK2126458 ≥98% | 1086062-66-9 | 5mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 17377 | GSK2126458 ≥98% | 1086062-66-9 | 10mg | $380 | 2024-03-01 | Buy |
GSK-2126458 Chemical Properties,Uses,Production
Description
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.
Uses
A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.
Definition
ChEBI: Omipalisib is a member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors. It has a role as an autophagy inducer, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a mTOR inhibitor, an antineoplastic agent, a radiosensitizing agent and an anticoronaviral agent. It is a member of quinolines, a difluorobenzene, a sulfonamide, an aromatic ether, a member of pyridines and a member of pyridazines.
target
p110α
storage
Store at -20°C
GSK-2126458 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29793 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
View Lastest Price from GSK-2126458 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | Omipalisib
1086062-66-9
|
US $57.00-178.00 / mg | 99.8% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | GSK-2126458
1086062-66-9
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Omipalisib
1086062-66-9
- US $57.00-178.00 / mg
- 99.8%
- TargetMol Chemicals Inc.
-
- GSK-2126458
1086062-66-9
- US $2.00 / kg
- 99%
- Career Henan Chemical Co