CID-49830258
- CAS No.
- 1346527-98-7
- Chemical Name:
- CID-49830258
- Synonyms
- ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
- CBNumber:
- CB92751093
- Molecular Formula:
- C23H20N6O
- Molecular Weight:
- 396.44
- MDL Number:
- MFCD28137687
- MOL File:
- 1346527-98-7.mol
- MSDS File:
- SDS
CID-49830258 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1071 | ML240 ≥98% (HPLC) | 1346527-98-7 | 5mg | $81 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1071 | ML240 ≥98% (HPLC) | 1346527-98-7 | 25mg | $535 | 2024-03-01 | Buy |
| Cayman Chemical | 17373 | ML-240 ≥95% | 1346527-98-7 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17373 | ML-240 ≥95% | 1346527-98-7 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17373 | ML-240 ≥95% | 1346527-98-7 | 10mg | $168 | 2024-03-01 | Buy |
CID-49830258 Chemical Properties,Uses,Production
Uses
ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.
Uses
ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.
Definition
ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.
Biochem/physiol Actions
ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.
storage
Store at +4°C
CID-49830258 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32038 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38463 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
