ML414(NGI-1)
- CAS No.
- 790702-57-7
- Chemical Name:
- ML414(NGI-1)
- Synonyms
- NGI-1;ML414;NGI1 NEW;ML414(NGI-1);NGI-1 (ML414);ML-414;ML414;NGI 1;NGI-1 >=95% (HPLC);NGI-1, 10 mM in DMSO;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;ML 414,inhibit,Inhibitor,NGI 1,ML-414,NGI-1,Virus Protease,NGI1
- CBNumber:
- CB94664139
- Molecular Formula:
- C17H22N4O3S2
- Molecular Weight:
- 394.51
- MDL Number:
- MFCD06358908
- MOL File:
- 790702-57-7.mol
| Density | 1.372±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 5 mg/ml) |
| pka | 7.48±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ML414(NGI-1) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1620 | NGI-1 ≥95% (HPLC) | 790702-57-7 | 5mg | $108 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1620 | NGI-1 ≥95% (HPLC) | 790702-57-7 | 25mg | $261 | 2024-03-01 | Buy |
| Tocris | 6652 | NGI1 ≥98%(HPLC) | 790702-57-7 | 25 | $181 | 2021-12-16 | Buy |
| Tocris | 6652 | NGI1 ≥98%(HPLC) | 790702-57-7 | 5 | $78 | 2021-12-16 | Buy |
| TRC | D477148 | 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide | 790702-57-7 | 5mg | $130 | 2021-12-16 | Buy |
ML414(NGI-1) Chemical Properties,Uses,Production
Description
NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.
Uses
NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B[1]. NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability[2].
storage
Store at +4°C
References
1) Lopez-Sambrooks et al. (2016), Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells; Nature Chem. Biol. 12 1023 2) Puschnik et al. (2017), A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity; Cell Rep. 21 3032 3) Lopez-Sambrooks et al. (2018), Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors; Cancer Res. July 19, 2018 Epub ahead of print 4) Baro et al. (2018), Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity; Clin. Cancer Res. July 2, 2018 Epub ahead of print
ML414(NGI-1) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32197 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38635 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
790702-57-7(ML414(NGI-1))Related Search:
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benz amide ML414(NGI-1) ML414 NGI-1 NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、 NGI-1 (ML414) 5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide ML-414;ML414;NGI 1 NGI1 NEW 5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide 5-(N,N-Dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide ML 414,inhibit,Inhibitor,NGI 1,ML-414,NGI-1,Virus Protease,NGI1 NGI-1, 10 mM in DMSO 790702-57-7 API